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kallikrein related peptidase 5

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Target not currently curated in GtoImmuPdb

Target id: 2375

Nomenclature: kallikrein related peptidase 5

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 293 19q13.33 KLK5 kallikrein related peptidase 5
Mouse - 293 7 B4 Klk5 kallikrein related-peptidase 5
Rat - - q22 Klk5 kallikrein related-peptidase 5
Previous and Unofficial Names Click here for help
kallikrein 5 | kallikrein-5 | KLK-L2 | SCTE | kallikrein-related peptidase 5
Database Links Click here for help
Specialist databases
MEROPS S01.017 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 23849879] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.7x10-7 M) [1]
compound 4d [PMID: 25489658] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 2
pIC50 6.0 (IC50 9.2x10-7 M) [2]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002803 positive regulation of antibacterial peptide production IMP

References

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1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg. Med. Chem. Lett., 23 (16): 4547-51. [PMID:23849879]

2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J. Med. Chem., 58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 5. Last modified on 29/01/2016. Accessed on 31/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2375.