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kallikrein related peptidase 3

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Target not currently curated in GtoImmuPdb

Target id: 2373

Nomenclature: kallikrein related peptidase 3

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 19q13.33 KLK3 kallikrein related peptidase 3
Mouse - 263 7 28.54 cM Klk1b27 kallikrein 1-related peptidase b27
Previous and Unofficial Names Click here for help
APS | Gk27 | glandular kallikrein 27 | kallikrein 27 | Prostate-specific antigen | PSA | tissue kallikrein 27 | kallikrein-related peptidase 3
Database Links Click here for help
Specialist databases
MEROPS S01.162 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 20 [PMID: 23692593] Small molecule or natural product Primary target of this compound Hs Inhibition 7.1 pKi 1
pKi 7.1 (Ki 7.2x10-8 M) [1]
Description: PSA isolated from human seminal plasma.


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1. Kostova MB, Rosen DM, Chen Y, Mease RC, Denmeade SR. (2013) Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors. J Med Chem, 56 (11): 4224-35. [PMID:23692593]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 3. Last modified on 29/01/2016. Accessed on 26/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,