kallikrein related peptidase 3 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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kallikrein related peptidase 3

Target not currently curated in GtoImmuPdb

Target id: 2373

Nomenclature: kallikrein related peptidase 3

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 19q13.41 KLK3 kallikrein related peptidase 3
Mouse - 263 7 B4 Klk1b27 kallikrein 1-related peptidase b27
Previous and Unofficial Names
APS | Gk27 | glandular kallikrein 27 | kallikrein 27 | Prostate-specific antigen | PSA | tissue kallikrein 27 | kallikrein-related peptidase 3
Database Links
Specialist databases
MEROPS S01.162 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 20 [PMID: 23692593] Hs Inhibition 7.1 pKi 1
pKi 7.1 (Ki 7.2x10-8 M) [1]
Description: PSA isolated from human seminal plasma.


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1. Kostova MB, Rosen DM, Chen Y, Mease RC, Denmeade SR. (2013) Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors. J. Med. Chem., 56 (11): 4224-35. [PMID:23692593]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 3. Last modified on 29/01/2016. Accessed on 23/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2373.