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coagulation factor VII

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Target not currently curated in GtoImmuPdb

Target id: 2363

Nomenclature: coagulation factor VII

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 466 13q34 F7 coagulation factor VII
Mouse - 446 8 5.73 cM F7 coagulation factor VII
Rat - 446 16q12.5 F7 coagulation factor VII
Previous and Unofficial Names Click here for help
factor VII | Cf7 | eptacog alfa | FVII | serum prothrombin conversion accelerator | coagulation factor VII (serum prothrombin conversion accelerator)
Database Links Click here for help
Specialist databases
MEROPS S01.215 (Hs)
Other databases
Alphafold P08709 (Hs), P70375 (Mm), Q8K3U6 (Rn)
BRENDA 3.4.21.21
CATH/Gene3D 4.10.740.10
ChEMBL Target CHEMBL3991 (Hs)
DrugBank Target P08709 (Hs)
Ensembl Gene ENSG00000057593 (Hs), ENSMUSG00000031443 (Mm), ENSRNOG00000032737 (Rn)
Entrez Gene 2155 (Hs), 14068 (Mm), 260320 (Rn)
Human Protein Atlas ENSG00000057593 (Hs)
KEGG Enzyme 3.4.21.21
KEGG Gene hsa:2155 (Hs), mmu:14068 (Mm), rno:260320 (Rn)
OMIM 613878 (Hs)
Orphanet ORPHA121675 (Hs)
Pharos P08709 (Hs)
RefSeq Nucleotide NM_000131 (Hs), NM_019616 (Hs), NM_010172 (Mm), NM_152846 (Rn)
RefSeq Protein NP_000122 (Hs), NP_062562 (Hs), NP_034302 (Mm), NP_690059 (Rn)
UniProtKB P08709 (Hs), P70375 (Mm), Q8K3U6 (Rn)
Wikipedia F7 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.21

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1 [PMID: 16650987] Small molecule or natural product Hs Inhibition 9.0 pKi 2
⤷ pKi 9.0 (Ki 1x10-9 M) [2]
compound 11 [PMID: 16413183] Small molecule or natural product Click here for species-specific activity table Hs Inhibition ~7.0 pKi 3
⤷ pKi ~7.0 (Ki ~1x10-7 M) [3]
Description: Ki calculated from fold selectivity for KLKB1.
PCI-27483 Small molecule or natural product Hs Inhibition - - 1
⤷ [1]
Description: Inhibits activated FV!!
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Chemotaxis & migration
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Factor VII deficiency
Disease Ontology: DOID:2215
OMIM: 227500
Orphanet: ORPHA327

References

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1. Dickman DA, Kumar DV, O'bryan C, Rai R, Shrader WD, Wesson K. (2005) Factor viia inhibitor. Patent number: WO2005118554A2. Assignee: Pharmacyclics, Inc.. Priority date: 02/06/2004. Publication date: 15/12/2005.

2. Vijaykumar D, Rai R, Shaghafi M, Ton T, Torkelson S, Leahy EM, Riggs JR, Hu H, Sprengeler PA, Shrader WD et al.. (2006) Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg Med Chem Lett, 16 (14): 3829-32. [PMID:16650987]

3. Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. (2006) Small molecule inhibitors of plasma kallikrein. Bioorg Med Chem Lett, 16 (7): 2034-6. [PMID:16413183]

How to cite this page

S1: Chymotrypsin: coagulation factor VII. Last modified on 11/01/2023. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363.