PCI-27483   Click here for help

GtoPdb Ligand ID: 11585

Synonyms: Example 1 [WO2005118554A2] | PCI27483
Compound class: Synthetic organic
Comment: PCI-27483 is a small molecule inhibitor of activated factor VII (FVIIa). A complex of FVIIa and tissue factor are involved in promoting cell migration and angiogenesis and may contribute to tumour invasiveness via this mechanism. Inhibiting FVIIa is being investigated for anti-tumour potential [3].

PCI-27483 is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 12
Hydrogen bond donors 9
Rotatable bonds 11
Topological polar surface area 291.25
Molecular weight 596.13
XLogP -1.46
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C(N[C@H](C(=O)O)CC(=O)O)Cc1cc(c2nc3c([nH]2)cc(cc3)C(=N)N)c(c(c1)c1cc(ccc1O)S(=O)(=O)N)O
Isomeric SMILES O=C(N[C@H](C(=O)O)CC(=O)O)Cc1cc(c2nc3c([nH]2)cc(cc3)C(=N)N)c(c(c1)c1cc(ccc1O)S(=O)(=O)N)O
InChI InChI=1S/C26H24N6O9S/c27-24(28)12-1-3-17-18(8-12)32-25(31-17)16-6-11(7-21(34)30-19(26(38)39)10-22(35)36)5-15(23(16)37)14-9-13(42(29,40)41)2-4-20(14)33/h1-6,8-9,19,33,37H,7,10H2,(H3,27,28)(H,30,34)(H,31,32)(H,35,36)(H,38,39)(H2,29,40,41)/t19-/m0/s1
InChI Key WDJHHCAKBRKCLW-IBGZPJMESA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Synonyms Click here for help
Example 1 [WO2005118554A2] | PCI27483
Database Links Click here for help
CAS Registry No. 871266-63-6 (source: PubChem)
ChEMBL Ligand CHEMBL4297315
DrugBank Ligand DB13000
GtoPdb PubChem SID 442878619
PubChem CID 135425273
Search Google for chemical match using the InChIKey WDJHHCAKBRKCLW-IBGZPJMESA-N
Search Google for chemicals with the same backbone WDJHHCAKBRKCLW
UniChem Compound Search for chemical match using the InChIKey WDJHHCAKBRKCLW-IBGZPJMESA-N
UniChem Connectivity Search for chemical match using the InChIKey WDJHHCAKBRKCLW-IBGZPJMESA-N

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MedChemExpress
PCI-27483 (links to external site)
Cat. No. HY-16382