Synonyms: Example 1 [WO2005118554A2] | PCI27483
Compound class:
Synthetic organic
Comment: PCI-27483 is a small molecule inhibitor of activated factor VII (FVIIa). A complex of FVIIa and tissue factor are involved in promoting cell migration and angiogenesis and may contribute to tumour invasiveness via this mechanism. Inhibiting FVIIa is being investigated for anti-tumour potential [3].
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Bioactivity Comments |
PCI-27483 is claimed in Pharmacyclics' patent WO2005118554A2 [1], but they do not provide a quantitative value for its inhibitory potency. It is able to inhibit viral entry in an in vitro SARS-CoV-2 spike pseudotyped particle entry assay [2], likely via weak inhibition of the serine protease TMPRSS2. |
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