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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 810 | 6q26 | PLG | plasminogen | |
Mouse | - | 812 | 17 8.5 cM | Plg | plasminogen | |
Rat | - | 812 | 1q11 | Plg | plasminogen |
Previous and Unofficial Names ![]() |
angiostatin | Pg |
Database Links ![]() |
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Specialist databases | |
MEROPS | S01.233 (Hs) |
Other databases | |
Alphafold | P00747 (Hs), P20918 (Mm), Q01177 (Rn) |
BRENDA | 3.4.21.7 |
ChEMBL Target | CHEMBL1801 (Hs), CHEMBL1075299 (Mm), CHEMBL3204 (Rn) |
DrugBank Target | P00747 (Hs) |
Ensembl Gene | ENSG00000122194 (Hs), ENSMUSG00000059481 (Mm), ENSRNOG00000017223 (Rn) |
Entrez Gene | 5340 (Hs), 18815 (Mm), 85253 (Rn) |
Human Protein Atlas | ENSG00000122194 (Hs) |
KEGG Enzyme | 3.4.21.7 |
KEGG Gene | hsa:5340 (Hs), mmu:18815 (Mm), rno:85253 (Rn) |
OMIM | 173350 (Hs) |
Orphanet | ORPHA117886 (Hs) |
Pharos | P00747 (Hs) |
RefSeq Nucleotide | NM_000301 (Hs), NM_008877 (Mm), NM_053491 (Rn) |
RefSeq Protein | NP_000292 (Hs), NP_032903 (Mm), NP_445943 (Rn) |
SynPHARM |
78429 (in complex with 6-aminocaproic acid) 78427 (in complex with tranexamic acid) |
UniProtKB | P00747 (Hs), P20918 (Mm), Q01177 (Rn) |
Wikipedia | PLG (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlen S, Jonforsen M, Plowright AT, Bostrom J et al.. (2014) Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS Med Chem Lett, 5 (5): 538-543. [PMID:24900876]
2. Saupe SM, Steinmetzer T. (2012) A new strategy for the development of highly potent and selective plasmin inhibitors. J Med Chem, 55 (3): 1171-80. [PMID:22276953]
3. Setyono-Han B, Stürzebecher J, Schmalix WA, Muehlenweg B, Sieuwerts AM, Timmermans M, Magdolen V, Schmitt M, Klijn JG, Foekens JA. (2005) Suppression of rat breast cancer metastasis and reduction of primary tumour growth by the small synthetic urokinase inhibitor WX-UK1. Thromb Haemost, 93 (4): 779-86. [PMID:15841327]
4. Sperzel M, Huetter J. (2007) Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J Thromb Haemost, 5 (10): 2113-8. [PMID:17666018]
S1: Chymotrypsin: plasminogen. Last modified on 17/05/2022. Accessed on 19/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2394.