Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	810	6q26	PLG	plasminogen
Mouse	-	812	17 A1	Plg	plasminogen
Rat	-	812	1q11	Plg	plasminogen

Previous and Unofficial Names

Pg | angiostatin

Database Links
Specialist databases
MEROPS	S01.233 (Hs)
Other databases
BRENDA	3.4.21.7
ChEMBL Target	CHEMBL1801 (Hs), CHEMBL1075299 (Mm), CHEMBL3204 (Rn)
DrugBank Target	P00747 (Hs)
Ensembl Gene	ENSG00000122194 (Hs), ENSMUSG00000059481 (Mm), ENSRNOG00000017223 (Rn)
Entrez Gene	5340 (Hs), 18815 (Mm), 85253 (Rn)
Human Protein Atlas	ENSG00000122194 (Hs)
KEGG Enzyme	3.4.21.7
KEGG Gene	hsa:5340 (Hs), mmu:18815 (Mm), rno:85253 (Rn)
OMIM	173350 (Hs)
Orphanet	ORPHA117886 (Hs)
RefSeq Nucleotide	NM_000301 (Hs), NM_008877 (Mm), NM_053491 (Rn)
RefSeq Protein	NP_000292 (Hs), NP_032903 (Mm), NP_445943 (Rn)
SynPHARM	78429 (in complex with 6-aminocaproic acid) 78427 (in complex with tranexamic acid)
UniProtKB	P00747 (Hs), P20918 (Mm), Q01177 (Rn)
Wikipedia	PLG (Hs)

Enzyme Reaction
EC Number: 3.4.21.7

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference bis-triazole derivative 10 Hs Inhibition 9.1 pKi 2 ⤷ pKi 9.1 (Ki 7.7x10-10 M) [2] aprotinin {Sp: Bovine} Hs Binding 6.8 pIC50 3 ⤷ pIC50 6.8 (IC50 1.6x10-7 M) [3] 6-aminocaproic acid Hs Binding 4.4 pIC50 1 ⤷ pIC50 4.4 (IC50 4x10-5 M) [1] Description: Measuring inhibition of fibrinolysis in plasma. tranexamic acid Hs Binding 3.6 pIC50 3 ⤷ pIC50 3.6 (IC50 2.41x10-4 M) [3]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Hypoplasminogenemia Synonyms: Plasminogen deficiency type 1 OMIM: 217090 Orphanet: ORPHA722
Disease:  Ligneous conjunctivitis OMIM: 217090 Orphanet: ORPHA97231