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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 810 | 6q26 | PLG | plasminogen | |
Mouse | - | 812 | 17 8.5 cM | Plg | plasminogen | |
Rat | - | 812 | 1q11 | Plg | plasminogen |
Previous and Unofficial Names ![]() |
angiostatin | Pg |
Database Links ![]() |
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Specialist databases | |
MEROPS | S01.233 (Hs) |
Other databases | |
BRENDA | 3.4.21.7 |
ChEMBL Target | CHEMBL1801 (Hs), CHEMBL1075299 (Mm), CHEMBL3204 (Rn) |
DrugBank Target | P00747 (Hs) |
Ensembl Gene | ENSG00000122194 (Hs), ENSMUSG00000059481 (Mm), ENSRNOG00000017223 (Rn) |
Entrez Gene | 5340 (Hs), 18815 (Mm), 85253 (Rn) |
Human Protein Atlas | ENSG00000122194 (Hs) |
KEGG Enzyme | 3.4.21.7 |
KEGG Gene | hsa:5340 (Hs), mmu:18815 (Mm), rno:85253 (Rn) |
OMIM | 173350 (Hs) |
Orphanet | ORPHA117886 (Hs) |
Pharos | P00747 (Hs) |
RefSeq Nucleotide | NM_000301 (Hs), NM_008877 (Mm), NM_053491 (Rn) |
RefSeq Protein | NP_000292 (Hs), NP_032903 (Mm), NP_445943 (Rn) |
SynPHARM |
78429 (in complex with 6-aminocaproic acid) 78427 (in complex with tranexamic acid) |
UniProtKB | P00747 (Hs), P20918 (Mm), Q01177 (Rn) |
Wikipedia | PLG (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||||||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlen S, Jonforsen M, Plowright AT, Bostrom J et al.. (2014) Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS Med Chem Lett, 5 (5): 538-543. [PMID:24900876]
2. Saupe SM, Steinmetzer T. (2012) A new strategy for the development of highly potent and selective plasmin inhibitors. J. Med. Chem., 55 (3): 1171-80. [PMID:22276953]
3. Sperzel M, Huetter J. (2007) Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J. Thromb. Haemost., 5 (10): 2113-8. [PMID:17666018]
S1: Chymotrypsin: plasminogen. Last modified on 07/09/2015. Accessed on 28/02/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2394.