plasminogen | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 2394

Nomenclature: plasminogen

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 810 6q26 PLG plasminogen
Mouse - 812 17 A1 Plg plasminogen
Rat - 812 1q11 Plg plasminogen
Previous and Unofficial Names
angiostatin | Pg
Database Links
Specialist databases
MEROPS S01.233 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
bis-triazole derivative 10 Hs Inhibition 9.1 pKi 2
pKi 9.1 (Ki 7.7x10-10 M) [2]
aprotinin {Sp: Bovine} Hs Binding 6.8 pIC50 3
pIC50 6.8 (IC50 1.6x10-7 M) [3]
6-aminocaproic acid Hs Binding 4.4 pIC50 1
pIC50 4.4 (IC50 4x10-5 M) [1]
Description: Measuring inhibition of fibrinolysis in plasma.
tranexamic acid Hs Binding 3.6 pIC50 3
pIC50 3.6 (IC50 2.41x10-4 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hypoplasminogenemia
Synonyms: Plasminogen deficiency type 1
OMIM: 217090
Orphanet: ORPHA722
Disease:  Ligneous conjunctivitis
OMIM: 217090
Orphanet: ORPHA97231


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1. Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlen S, Jonforsen M, Plowright AT, Bostrom J et al.. (2014) Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS Med Chem Lett, 5 (5): 538-543. [PMID:24900876]

2. Saupe SM, Steinmetzer T. (2012) A new strategy for the development of highly potent and selective plasmin inhibitors. J. Med. Chem., 55 (3): 1171-80. [PMID:22276953]

3. Sperzel M, Huetter J. (2007) Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J. Thromb. Haemost., 5 (10): 2113-8. [PMID:17666018]

How to cite this page

S1: Chymotrypsin: plasminogen. Last modified on 07/09/2015. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,