aprotinin   Click here for help

GtoPdb Ligand ID: 6570

Synonyms: basic protease inhibitor (BPI) | BPTI | pancreatic trypsin inhibitor | Trasylol®
Approved drug
aprotinin is an approved drug (FDA (1993))
Compound class: Peptide or derivative
Comment: 58 amino-acid residue inhibitor of plasmin and other proteolytic enzymes.
Species: Bovine
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

aprotinin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)CNC(=O)CNC(=O)[C@H](Cc4ccc(cc4)O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CCCNC(=N)N)C)CCCCN)CCCNC(=N)N)CC(=O)N)CC(=O)N)Cc3ccccc3)CCCCN)CO)C)CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3[C@H](C(=O)N4[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N5[C@H](C(=O)N2)CCC5)[C@H](O)C)Cc2ccc(cc2)O)CCC4)CCC3)CCC(=O)O)CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=N)N)N)CC(=O)O)Cc2ccccc2)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)C)[C@H](O)C)CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C)CCCNC(=N)N)[C@H](CC)C)[C@H](CC)C)CCCNC(=N)N)Cc1ccc(cc1)O)Cc1ccccc1)Cc1ccc(cc1)O)CC(=O)N)C)CCCCN)C)[C@H](O)C)C(C)C
Isomeric SMILES CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N4CCC[C@H]4C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N4CCC[C@H]4C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3)CC(=O)O)CCC(=O)O)C)CO)CCCCN)Cc3ccccc3)CC(=O)N)CC(=O)N)CCCNC(=N)N)CCCCN)C)CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CCC(=O)N)[C@@H](C)O)Cc2ccccc2)C(C)C)Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)C)CCCCN)[C@@H](C)O)Cc1ccc(cc1)O)CCC(=O)O)CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)CCCNC(=N)N)CCSC)CC(C)C)C)CCCCN)C)CC(=O)N)Cc1ccc(cc1)O)Cc1ccccc1)Cc1ccc(cc1)O)CCCNC(=N)N)[C@@H](C)CC
InChI Key ZPNFWUPYTFPOJU-LPYSRVMUSA-N
Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (FDA (1993))
International Nonproprietary Names Click here for help
INN number INN
2481 aprotinin
Synonyms Click here for help
basic protease inhibitor (BPI) | BPTI | pancreatic trypsin inhibitor | Trasylol®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
BPTI PTI pancreatic trypsin inhibitor [ Bos taurus (cattle) ] Bovine Pancreatic trypsin inhibitor -
Database Links Click here for help
CAS Registry No. 9087-70-1 (source: PubChem)
DrugBank Ligand DB06692
GtoPdb PubChem SID 178103184
PubChem CID 16130295
Search Google for chemical match using the InChIKey ZPNFWUPYTFPOJU-LPYSRVMUSA-N
Search Google for chemicals with the same backbone ZPNFWUPYTFPOJU
Search PubMed clinical trials aprotinin
Search PubMed titles aprotinin
Search PubMed titles/abstracts aprotinin
UniChem Compound Search for chemical match using the InChIKey ZPNFWUPYTFPOJU-LPYSRVMUSA-N
UniChem Connectivity Search for chemical match using the InChIKey ZPNFWUPYTFPOJU-LPYSRVMUSA-N
UniProtKB P00974 (Bt)
Wikipedia Aprotinin

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