plasminogen | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 2394

Nomenclature: plasminogen

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 810 6q26 PLG plasminogen
Mouse - 812 17 A1 Plg plasminogen
Rat - 812 1q11 Plg plasminogen
Previous and Unofficial Names
Pg | angiostatin
Database Links
Specialist databases
MEROPS S01.233 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
bis-triazole derivative 10 Hs Inhibition 9.1 pKi 2
pKi 9.1 (Ki 7.7x10-10 M) [2]
aprotinin {Sp: Bovine} Hs Binding 6.8 pIC50 3
pIC50 6.8 (IC50 1.6x10-7 M) [3]
6-aminocaproic acid Hs Binding 4.4 pIC50 1
pIC50 4.4 (IC50 4x10-5 M) [1]
Description: Measuring inhibition of fibrinolysis in plasma.
tranexamic acid Hs Binding 3.6 pIC50 3
pIC50 3.6 (IC50 2.41x10-4 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hypoplasminogenemia
Synonyms: Plasminogen deficiency type 1
OMIM: 217090
Orphanet: ORPHA722
Disease:  Ligneous conjunctivitis
OMIM: 217090
Orphanet: ORPHA97231


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1. Cheng L, Pettersen D, Ohlsson B, Schell P, Karle M, Evertsson E, Pahlen S, Jonforsen M, Plowright AT, Bostrom J et al.. (2014) Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS Med Chem Lett, 5 (5): 538-543. [PMID:24900876]

2. Saupe SM, Steinmetzer T. (2012) A new strategy for the development of highly potent and selective plasmin inhibitors. J. Med. Chem., 55 (3): 1171-80. [PMID:22276953]

3. Sperzel M, Huetter J. (2007) Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. J. Thromb. Haemost., 5 (10): 2113-8. [PMID:17666018]

How to cite this page

S1: Chymotrypsin: plasminogen. Last modified on 07/09/2015. Accessed on 16/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,