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complement C1r

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2334

Nomenclature: complement C1r

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 705 12p13.31 C1R complement C1r
Mouse - 707 6 F2 C1ra complement component 1, r subcomponent A
Rat - 707 4q42 C1r complement C1r
Previous and Unofficial Names Click here for help
complement C1r-A subcomponent | complement component 1, r subcomponent A | complement component 1
Database Links Click here for help
Specialist databases
MEROPS S01.192 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.41

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
nafamostat Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 4.9 pIC50 1
pIC50 4.9 (IC50 1.2x10-5 M) [1]
Immunopharmacology Comments
A protease component of the C1-complex of the classical complement pathway.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0006958 complement activation, classical pathway TAS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0006958 complement activation, classical pathway TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0006956 complement activation TAS
GO:0006958 complement activation, classical pathway TAS
GO:0030449 regulation of complement activation TAS
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Complement component C1r/C1s deficiency
Synonyms: Immunodeficiency due to an early component of complement deficiency [Orphanet: ORPHA169147]
OMIM: 216950
Orphanet: ORPHA169147

References

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1. Hays SJ, Caprathe BW, Gilmore JL, Amin N, Emmerling MR, Michael W, Nadimpalli R, Nath R, Raser KJ, Stafford D et al.. (1998) 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J. Med. Chem., 41 (7): 1060-7. [PMID:9544206]

How to cite this page

S1: Chymotrypsin: complement C1r. Last modified on 17/02/2017. Accessed on 03/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2334.