apixaban

Ligand id: 6390

Name: apixaban

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View more information in the IUPHAR Pharmacology Education Project: apixaban

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 110.24
Molecular weight 459.19
XLogP 1.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Classification
Compound class Synthetic organic
Approved drug? Yes (EMA (2011), FDA (2012))
IUPAC Name
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
International Nonproprietary Names
INN number INN
8626 apixaban
Synonyms
BMS-562247 | Eliquis®
Comments
Apixaban belongs to the direct factor Xa inhibitor family of drugs, which also includes rivaroxaban and edoxaban.
Database Links
CAS Registry No. 503612-47-3 (source: PubChem)
ChEBI CHEBI:72296
ChEMBL Ligand CHEMBL231779
DrugBank Ligand DB06605
GtoPdb PubChem SID 178103006
PubChem CID 10182969
RCSB PDB Ligand GG2
Search Google for chemical match using the InChIKey QNZCBYKSOIHPEH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QNZCBYKSOIHPEH
Search PubMed clinical trials apixaban
Search PubMed titles apixaban
Search PubMed titles/abstracts apixaban
Search UniChem for chemical match using the InChIKey QNZCBYKSOIHPEH-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone QNZCBYKSOIHPEH
SynPHARM 78505 (in complex with coagulation factor X)
Wikipedia Apixaban