ChEMBL ligand: CHEMBL231779 (Apixaban, BMS-562247, BMS-562247-01, Eliquis)
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] Coagulation factor X in Rabbit [ChEMBL: CHEMBL5062] [UniProtKB: O19045] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of human factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2007) 17: 4419-4427 [PMID:17588746]
ChEMBL	Binding affinity to human F10a	B	10.1	pKi	0.08	nM	Ki	J Med Chem (2007) 50: 5339-5356 [PMID:17914785]
ChEMBL	Inhibition of human factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2845-2849 [PMID:18424044]
ChEMBL	Inhibition of Factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2179-2185 [PMID:19297154]
ChEMBL	Binding affinity to human coagulation factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2009) 19: 462-468 [PMID:19046881]
ChEMBL	Inhibition of human factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1373-1377 [PMID:20100660]
ChEMBL	Inhibition of factor 10a	B	10.1	pKi	0.08	nM	Ki	J Med Chem (2010) 53: 6243-6274 [PMID:20503967]
ChEMBL	Inhibition of purified human factor Xa	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2014) 24: 3341-3345 [PMID:24951330]
ChEMBL	Inhibition of factor Xa (unknown origin) assessed as inhibition constant	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2023) 80: 129127-129127 [PMID:36634753]
GtoPdb	-	-	10.1	pKi	0.08	nM	Ki	J Thromb Haemost (2008) 6: 820-9 [PMID:18315548]
ChEMBL	Inhibition of human coagulation factor 10a assessed as reduction in p-nitroaniline cleavage from pefachrome substrate preincubated for 10 mins followed by substrate addition measured after 20 mins	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem (2016) 24: 5646-5661 [PMID:27663548]
ChEMBL	Inhibition of human F10a assessed as decrease in p-nitroaniline cleavage from pefachrome F10a preincubated for 10 mins followed by substrate addition measured after 20 mins	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem (2017) 25: 2800-2810 [PMID:28389110]
ChEMBL	Inhibition of factor Xa (unknown origin)	B	8.65	pIC50	2.26	nM	IC50	Bioorg Med Chem Lett (2023) 80: 129127-129127 [PMID:36634753]
Coagulation factor X in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5062] [UniProtKB: O19045]
ChEMBL	Binding affinity to rabbit F10a	B	9.77	pKi	0.17	nM	Ki	J Med Chem (2007) 50: 5339-5356 [PMID:17914785]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Inhibition of human thrombin	B	5.51	pKi	3100	nM	Ki	J Med Chem (2007) 50: 5339-5356 [PMID:17914785]
ChEMBL	Inhibition of human factor 2a	B	5.51	pKi	3100	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1373-1377 [PMID:20100660]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]