transmembrane serine protease 6 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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transmembrane serine protease 6

Target not currently curated in GtoImmuPdb

Target id: 2422

Nomenclature: transmembrane serine protease 6

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 811 22q13.1 TMPRSS6 transmembrane serine protease 6
Mouse - 811 15 E2 Tmprss6 transmembrane serine protease 6
Rat - 772 7q34 Tmprss6 transmembrane serine protease 6
Previous and Unofficial Names
matriptase 2 | transmembrane protease serine 6 | transmembrane protease
Database Links
Specialist databases
MEROPS S01.308 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
inhibitor 1 [Colombo et al., 2012] Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3.3x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Iron-refractory iron deficiency anemia; IRIDA
Synonyms: IRIDA syndrome [Orphanet: ORPHA209981]
OMIM: 206200
Orphanet: ORPHA209981


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1. Colombo E, Desilets A, Duchene D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and Synthesis of Potent, Selective Inhibitors of Matriptase. ACS Med.Chem.Lett., 3: 530-534.

How to cite this page

S1: Chymotrypsin: transmembrane serine protease 6. Last modified on 27/02/2018. Accessed on 23/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,