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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 811 | 22q12.3 | TMPRSS6 | transmembrane serine protease 6 | |
Mouse | 1 | 811 | 15 E1 | Tmprss6 | transmembrane serine protease 6 | |
Rat | - | 772 | 7q34 | Tmprss6 | transmembrane serine protease 6 |
Previous and Unofficial Names ![]() |
matriptase 2 | transmembrane protease serine 6 | transmembrane protease |
Database Links ![]() |
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Specialist databases | |
MEROPS | S01.308 (Hs) |
Other databases | |
Alphafold | Q8IU80 (Hs), Q9DBI0 (Mm) |
BRENDA | 3.4.21.- |
CATH/Gene3D | 2.60.120.290, 3.30.70.960 |
ChEMBL Target | CHEMBL1795139 (Hs) |
Ensembl Gene | ENSG00000187045 (Hs), ENSMUSG00000016942 (Mm), ENSRNOG00000000184 (Rn) |
Entrez Gene | 164656 (Hs), 71753 (Mm), 315388 (Rn) |
Human Protein Atlas | ENSG00000187045 (Hs) |
KEGG Enzyme | 3.4.21.- |
KEGG Gene | hsa:164656 (Hs), mmu:71753 (Mm), rno:315388 (Rn) |
OMIM | 609862 (Hs) |
Orphanet | ORPHA139780 (Hs) |
Pharos | Q8IU80 (Hs) |
RefSeq Nucleotide | NM_153609 (Hs), NM_027902 (Mm), NM_001130556 (Rn) |
RefSeq Protein | NP_705837 (Hs), NP_082178 (Mm), NP_001124028 (Rn) |
UniProtKB | Q8IU80 (Hs), Q9DBI0 (Mm) |
Wikipedia | TMPRSS6 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and synthesis of potent, selective inhibitors of matriptase. ACS Med Chem Lett, 3 (7): 530-4. [PMID:24900505]
2. Desgagné M, Désilets A, Ferková S, Lepage M, Perreault O, Joushomme A, Lemieux G, Guerrab W, Froehlich U, Comeau C et al.. (2024) Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket. J Med Chem, 67 (15): 12969-12983. [PMID:39028865]
S1: Chymotrypsin: transmembrane serine protease 6. Last modified on 22/07/2024. Accessed on 16/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2422.