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transmembrane serine protease 6

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Target not currently curated in GtoImmuPdb

Target id: 2422

Nomenclature: transmembrane serine protease 6

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 811 22q12.3 TMPRSS6 transmembrane serine protease 6
Mouse 1 811 15 E1 Tmprss6 transmembrane serine protease 6
Rat - 772 7q34 Tmprss6 transmembrane serine protease 6
Previous and Unofficial Names Click here for help
matriptase 2 | transmembrane protease serine 6 | transmembrane protease
Database Links Click here for help
Specialist databases
MEROPS S01.308 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
inhibitor 1 [Colombo et al., 2012] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3.3x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Iron-refractory iron deficiency anemia; IRIDA
Synonyms: IRIDA syndrome [Orphanet: ORPHA209981]
OMIM: 206200
Orphanet: ORPHA209981


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1. Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and synthesis of potent, selective inhibitors of matriptase. ACS Med Chem Lett, 3 (7): 530-4. [PMID:24900505]

How to cite this page

S1: Chymotrypsin: transmembrane serine protease 6. Last modified on 27/02/2018. Accessed on 23/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,