Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	811	22q12.3	TMPRSS6	transmembrane serine protease 6
Mouse	1	811	15 E1	Tmprss6	transmembrane serine protease 6
Rat	-	772	7q34	Tmprss6	transmembrane serine protease 6

Previous and Unofficial Names

matriptase 2 | transmembrane protease serine 6 | transmembrane protease

Database Links
Specialist databases
MEROPS	S01.308 (Hs)
Other databases
Alphafold	Q8IU80 (Hs), Q9DBI0 (Mm)
BRENDA	3.4.21.-
CATH/Gene3D	2.60.120.290, 3.30.70.960
ChEMBL Target	CHEMBL1795139 (Hs)
Ensembl Gene	ENSG00000187045 (Hs), ENSMUSG00000016942 (Mm), ENSRNOG00000000184 (Rn)
Entrez Gene	164656 (Hs), 71753 (Mm), 315388 (Rn)
Human Protein Atlas	ENSG00000187045 (Hs)
KEGG Enzyme	3.4.21.-
KEGG Gene	hsa:164656 (Hs), mmu:71753 (Mm), rno:315388 (Rn)
OMIM	609862 (Hs)
Orphanet	ORPHA139780 (Hs)
Pharos	Q8IU80 (Hs)
RefSeq Nucleotide	NM_153609 (Hs), NM_027902 (Mm), NM_001130556 (Rn)
RefSeq Protein	NP_705837 (Hs), NP_082178 (Mm), NP_001124028 (Rn)
UniProtKB	Q8IU80 (Hs), Q9DBI0 (Mm)
Wikipedia	TMPRSS6 (Hs)

Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference inhibitor 1 [Colombo et al., 2012] Hs Inhibition 8.5 pKi 1 ⤷ pKi 8.5 (Ki 3.3x10-9 M) [1] MD5 Hs Inhibition 8.5 pKi 2 ⤷ pKi 8.5 (Ki 3.4x10-9 M) [2]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Iron-refractory iron deficiency anemia; IRIDA Synonyms: IRIDA syndrome [Orphanet: ORPHA209981] OMIM: 206200 Orphanet: ORPHA209981