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acrosin

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Target not currently curated in GtoImmuPdb

Target id: 2327

Nomenclature: acrosin

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 421 22q13.33 ACR acrosin
Mouse - 436 15 44.96 cM Acr acrosin prepropeptide
Rat - 437 7q34 Acr acrosin
Previous and Unofficial Names Click here for help
Acro
Database Links Click here for help
Specialist databases
MEROPS S01.223 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.10

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 9 [PMID: 3514912] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.5 pIC50 1
pIC50 8.5 (IC50 3.3x10-9 M) [1]

References

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1. Kaminski JM, Bauer L, Mack SR, Anderson Jr RA, Waller DP, Zaneveld LJ. (1986) Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates. J. Med. Chem., 29 (4): 514-9. [PMID:3514912]

How to cite this page

S1: Chymotrypsin: acrosin. Last modified on 14/07/2015. Accessed on 03/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2327.