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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 688 | 12p13.31 | C1S | complement C1s | |
Mouse | - | 688 | 6 F2 | C1s2 | complement component 1, s subcomponent 2 | |
Rat | - | 688 | 4q42 | C1s | complement C1s |
Previous and Unofficial Names ![]() |
C1sb | complement component C1SB | r-gsp | Gm5077 | predicted gene 5077 | complement component 1 | complement component 1, s subcomponent 2 |
Database Links ![]() |
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Specialist databases | |
MEROPS | S01.193 (Hs) |
Other databases | |
Alphafold | P09871 (Hs), Q8CFG8 (Mm), Q6P6T1 (Rn) |
BRENDA | 3.4.21.42 |
CATH/Gene3D | 2.60.120.290 |
ChEMBL Target | CHEMBL3913 (Hs) |
Ensembl Gene | ENSG00000182326 (Hs), ENSMUSG00000079343 (Mm), ENSRNOG00000011971 (Rn) |
Entrez Gene | 716 (Hs), 317677 (Mm), 192262 (Rn) |
Human Protein Atlas | ENSG00000182326 (Hs) |
KEGG Enzyme | 3.4.21.42 |
KEGG Gene | hsa:716 (Hs), mmu:317677 (Mm), rno:192262 (Rn) |
OMIM | 120580 (Hs) |
Orphanet | ORPHA221171 (Hs) |
Pharos | P09871 (Hs) |
RefSeq Nucleotide | NM_001734 (Hs), NM_201442 (Hs), NM_173864 (Mm), NM_138900 (Rn) |
RefSeq Protein | NP_001725 (Hs), NP_958850 (Hs), NP_776289 (Mm), NP_620255 (Rn) |
UniProtKB | P09871 (Hs), Q8CFG8 (Mm), Q6P6T1 (Rn) |
Wikipedia | C1S (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Antibodies | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Antibody Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
TNT009 binds to pro-C1s and mature C1s with the same affinity [1]. |
Immunopharmacology Comments |
A protease component of the C1-complex of the classical complement pathway. |
Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Panicker S, Parry G. (2016) Humanized anti-c1s antibodies and methods of use thereof. Patent number: WO2016164358A1. Assignee: True North Therapeutics, Inc.. Priority date: 06/04/2015. Publication date: 05/04/2016.
2. Subasinghe NL, Travins JM, Ali F, Huang H, Ballentine SK, Marugán JJ, Khalil E, Hufnagel HR, Bone RF, DesJarlais RL et al.. (2006) A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett, 16 (8): 2200-4. [PMID:16460935]
S1: Chymotrypsin: complement C1s. Last modified on 15/02/2018. Accessed on 07/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2335.