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complement C1s

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2335

Nomenclature: complement C1s

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 688 12p13.31 C1S complement C1s
Mouse - 688 6 F2 C1s2 complement component 1, s subcomponent 2
Rat - 688 4q42 C1s complement C1s
Previous and Unofficial Names Click here for help
C1sb | complement component C1SB | r-gsp | Gm5077 | predicted gene 5077 | complement component 1 | complement component 1, s subcomponent 2
Database Links Click here for help
Specialist databases
MEROPS S01.193 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 28 [PMID: 16460935] Small molecule or natural product Primary target of this compound Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1x10-8 M) [2]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
sutimlimab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 9.6 pKd 1
pKd 9.6 (Kd 2.6x10-10 M) [1]
Antibody Comments
TNT009 binds to pro-C1s and mature C1s with the same affinity [1].
Immunopharmacology Comments
A protease component of the C1-complex of the classical complement pathway.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Complement component C1s deficiency
Synonyms: Immunodeficiency due to an early component of complement deficiency [Orphanet: ORPHA169147]
OMIM: 613783
Orphanet: ORPHA169147


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1. Panicker S, Parry G. (2016) Humanized anti-c1s antibodies and methods of use thereof. Patent number: WO2016164358A1. Assignee: True North Therapeutics, Inc.. Priority date: 06/04/2015. Publication date: 05/04/2016.

2. Subasinghe NL, Travins JM, Ali F, Huang H, Ballentine SK, Marugán JJ, Khalil E, Hufnagel HR, Bone RF, DesJarlais RL et al.. (2006) A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett, 16 (8): 2200-4. [PMID:16460935]

How to cite this page

S1: Chymotrypsin: complement C1s. Last modified on 15/02/2018. Accessed on 01/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY,