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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 275 | 16p13.3 | TPSAB1 | tryptase alpha/beta 1 |
Previous and Unofficial Names ![]() |
tryptase-I | tryptase-II | tryptase-III | TPS1 | TPS2 | TPSB1 | tryptase alpha II |
Database Links ![]() |
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Specialist databases | |
MEROPS | S01.143 (Hs) |
Other databases | |
Alphafold | Q15661 (Hs) |
BRENDA | 3.4.21.59 |
ChEMBL Target | CHEMBL2617 (Hs) |
Ensembl Gene | ENSG00000172236 (Hs) |
Entrez Gene | 7177 (Hs) |
Human Protein Atlas | ENSG00000172236 (Hs) |
KEGG Enzyme | 3.4.21.59 |
KEGG Gene | hsa:7177 (Hs) |
OMIM | 191080 (Hs) |
Pharos | Q15661 (Hs) |
RefSeq Nucleotide | NM_003294 (Hs) |
RefSeq Protein | NP_003285 (Hs) |
UniProtKB | Q15661 (Hs) |
Wikipedia | TPSAB1 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
Inhibition of TPSAB1, released from mast cells in response to allergen exposure, abrogates the subsequent allergic airway response in vivo [1,3]: e.g. see inhibitor RWJ-58643. |
1. Costanzo MJ, Yabut SC, Almond Jr HR, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D et al.. (2003) Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone. J Med Chem, 46 (18): 3865-76. [PMID:12930148]
2. Erba F, Fiorucci L, Pascarella S, Menegatti E, Ascenzi P, Ascoli F. (2001) Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol, 61 (3): 271-6. [PMID:11172730]
3. Erin EM, Leaker BR, Zacharasiewicz A, Higgins LA, Nicholson GC, Boyce MJ, de Boer P, Jones RC, Durham SR, Barnes PJ et al.. (2006) Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses. Clin Exp Allergy, 36 (4): 458-64. [PMID:16630150]
4. Mori S, Itoh Y, Shinohata R, Sendo T, Oishi R, Nishibori M. (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J Pharmacol Sci, 92 (4): 420-3. [PMID:12939527]
S1: Chymotrypsin: tryptase alpha/beta 1. Last modified on 04/10/2016. Accessed on 18/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2424.