chymotrypsin C | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

chymotrypsin C

Target not currently curated in GtoImmuPdb

Target id: 2341

Nomenclature: chymotrypsin C

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 268 1p36.21 CTRC chymotrypsin C
Mouse - 268 4 E1 Ctrc chymotrypsin C (caldecrin)
Rat - 268 5q36 Ctrc chymotrypsin C
Previous and Unofficial Names
CLCR | ELA4 | elastase 4 | serum calcium-decreasing factor | chymotrypsin C (caldecrin)
Database Links
Specialist databases
MEROPS S01.157 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 20 [PMID: 12372533] Hs Inhibition 7.3 pKi 3
pKi 7.3 (Ki 5x10-8 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hereditary pancreatitis
Synonyms: Hereditary chronic pancreatitis [Orphanet: ORPHA676]
OMIM: 167800
Orphanet: ORPHA676
Disease:  Tropical pancreatitis
Orphanet: ORPHA103918
References:  1-2


Show »

1. Derikx MH, Szmola R, te Morsche RH, Sunderasan S, Chacko A, Drenth JP. (2009) Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. Eur J Gastroenterol Hepatol, 21 (8): 889-94. [PMID:19404200]

2. Paliwal S, Bhaskar S, Mani KR, Reddy DN, Rao GV, Singh SP, Thomas V, Chandak GR. (2013) Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. Gut, 62 (11): 1602-6. [PMID:22580415]

3. Priestley ES, De Lucca I, Ghavimi B, Erickson-Viitanen S, Decicco CP. (2002) P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease. Bioorg. Med. Chem. Lett., 12 (21): 3199-202. [PMID:12372533]

How to cite this page

S1: Chymotrypsin: chymotrypsin C. Last modified on 29/01/2016. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,