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serine protease 3

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Target not currently curated in GtoImmuPdb

Target id: 2399

Nomenclature: serine protease 3

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 304 9p13.3 PRSS3 serine protease 3
Mouse - 246 6 B1 Prss3 protease, serine 3
Rat - - q22 LOC679835 similar to Anionic trypsin II precursor (Pretrypsinogen II)
Previous and Unofficial Names Click here for help
mesotrypsin | MTG | protease | protease, serine, 3 | protease, serine 3 | PRSS4 | Try3 | TRY4 | trypsin 3 | trypsinogen 15
Database Links Click here for help
Specialist databases
MEROPS S01.174 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.4

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Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BPTI-K15R/R17G Peptide Hs Inhibition 8.2 pKi 1
pKi 8.2 (Ki 5.9x10-9 M) [1]
Inhibitor Comments
BPTI-K15R/R17G retains inhibitory activity towards human cationic trypsin and human anionic trypsin, but activity is weakened compared to wild type BPTI [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS

References

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1. Salameh MA, Soares AS, Hockla A, Radisky DC, Radisky ES. (2011) The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem. J., 440 (1): 95-105. [PMID:21806544]

How to cite this page

S1: Chymotrypsin: serine protease 3. Last modified on 27/02/2018. Accessed on 03/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2399.