serine protease 3 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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serine protease 3

Target not currently curated in GtoImmuPdb

Target id: 2399

Nomenclature: serine protease 3

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 304 9p13 PRSS3 serine protease 3
Mouse - 246 6 B1 Prss3 protease, serine 3
Rat - - q22 LOC679835 similar to Anionic trypsin II precursor (Pretrypsinogen II)
Previous and Unofficial Names
mesotrypsin | MTG | PRSS4 | Try3 | TRY4 | trypsin 3 | trypsinogen 15 | protease, serine, 3 | protease, serine 3 | protease
Database Links
Specialist databases
MEROPS S01.174 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BPTI-K15R/R17G Hs Inhibition 8.2 pKi 1
pKi 8.2 (Ki 5.9x10-9 M) [1]
Inhibitor Comments
BPTI-K15R/R17G retains inhibitory activity towards human cationic trypsin and human anionic trypsin, but activity is weakened compared to wild type BPTI [1].


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1. Salameh MA, Soares AS, Hockla A, Radisky DC, Radisky ES. (2011) The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem. J., 440 (1): 95-105. [PMID:21806544]

How to cite this page

S1: Chymotrypsin: serine protease 3. Last modified on 27/02/2018. Accessed on 23/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,