kallikrein related peptidase 14 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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kallikrein related peptidase 14

Target not currently curated in GtoImmuPdb

Target id: 2866

Nomenclature: kallikrein related peptidase 14

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 19q13.3-q13.4 KLK14 kallikrein related peptidase 14
Mouse - 250 7 B4 Klk14 kallikrein related-peptidase 14
Rat - - 1q22 Klk14 kallikrein related-peptidase 14
Previous and Unofficial Names
kallikrein-related peptidase 14
Database Links
Specialist databases
MEROPS S01.029 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 23849879] Hs Inhibition 5.9 pIC50 1
pIC50 5.9 (IC50 1.29x10-6 M) [1]
compound 4d [PMID: 25489658] Hs Inhibition 5.5 pIC50 2
pIC50 5.5 (IC50 2.9x10-6 M) [2]


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1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg. Med. Chem. Lett., 23 (16): 4547-51. [PMID:23849879]

2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J. Med. Chem., 58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 14. Last modified on 29/01/2016. Accessed on 08/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2866.