transmembrane serine protease 11D | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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transmembrane serine protease 11D

Target not currently curated in GtoImmuPdb

Target id: 2420

Nomenclature: transmembrane serine protease 11D

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 418 4q13.2 TMPRSS11D transmembrane serine protease 11D
Mouse - 417 5 E1 Tmprss11d transmembrane protease
Rat - 417 14p21 Tmprss11d transmembrane serine protease 11D
Previous and Unofficial Names
adrenal secretory serine protease | airway trypsin-like protease | Asp | AST | AT | transmembrane protease, serine 11d | transmembrane protease | transmembrane protease, serine 11D
Database Links
Specialist databases
MEROPS S01.047 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
inhibitor 1 [Colombo et al., 2012] Hs Inhibition 8.1 pKi 1
pKi 8.1 (Ki 8.4x10-9 M) [1]
compound 5 [PMID: 21741839] Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 1.9x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes
GO:0046718 viral entry into host cell ISO


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1. Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and synthesis of potent, selective inhibitors of matriptase. ACS Med Chem Lett, 3 (7): 530-4. [PMID:24900505]

2. Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg. Med. Chem. Lett., 21 (16): 4860-4. [PMID:21741839]

How to cite this page

S1: Chymotrypsin: transmembrane serine protease 11D. Last modified on 27/02/2018. Accessed on 04/06/2020. IUPHAR/BPS Guide to PHARMACOLOGY,