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transmembrane serine protease 11D

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Target not currently curated in GtoImmuPdb

Target id: 2420

Nomenclature: transmembrane serine protease 11D

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 418 4q13.2 TMPRSS11D transmembrane serine protease 11D
Mouse 1 417 5 E1 Tmprss11d transmembrane protease, serine 11d
Rat 1 417 14p21 Tmprss11d transmembrane serine protease 11D
Previous and Unofficial Names Click here for help
adrenal secretory serine protease | airway trypsin-like protease | Asp | AST | AT | transmembrane protease, serine 11d | transmembrane protease | transmembrane protease, serine 11D
Database Links Click here for help
Specialist databases
MEROPS S01.047 (Hs)
Other databases
BRENDA 3.4.21.-
CATH/Gene3D 3.30.70.960
ChEMBL Target CHEMBL1795138 (Hs)
Ensembl Gene ENSG00000153802 (Hs), ENSMUSG00000061259 (Mm), ENSRNOG00000002006 (Rn)
Entrez Gene 9407 (Hs), 231382 (Mm), 64565 (Rn)
Human Protein Atlas ENSG00000153802 (Hs)
KEGG Enzyme 3.4.21.-
KEGG Gene hsa:9407 (Hs), mmu:231382 (Mm), rno:64565 (Rn)
OMIM 605369 (Hs)
Pharos O60235 (Hs)
RefSeq Nucleotide NM_004262 (Hs), NM_145561 (Mm), NM_001033652 (Rn), NM_022630 (Rn)
RefSeq Protein NP_004253 (Hs), NP_663536 (Mm), NP_072152 (Rn), NP_001028824 (Rn)
UniProtKB O60235 (Hs), Q8VHK8 (Mm), Q8VHJ4 (Rn)
Wikipedia TMPRSS11D (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
inhibitor 1 [Colombo et al., 2012] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.1 pKi 1
⤷ pKi 8.1 (Ki 8.4x10-9 M) [1]
compound 5 [PMID: 21741839] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.7 pKi 2
⤷ pKi 7.7 (Ki 1.9x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes
GO:0046718 viral entry into host cell ISO

References

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1. Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and synthesis of potent, selective inhibitors of matriptase. ACS Med Chem Lett, 3 (7): 530-4. [PMID:24900505]

2. Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett, 21 (16): 4860-4. [PMID:21741839]

How to cite this page

S1: Chymotrypsin: transmembrane serine protease 11D. Last modified on 27/02/2018. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2420.