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transmembrane serine protease 11D

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Target not currently curated in GtoImmuPdb

Target id: 2420

Nomenclature: transmembrane serine protease 11D

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 418 4q13.2 TMPRSS11D transmembrane serine protease 11D
Mouse 1 417 5 E1 Tmprss11d transmembrane protease, serine 11d
Rat 1 417 14p21 Tmprss11d transmembrane serine protease 11D
Previous and Unofficial Names Click here for help
adrenal secretory serine protease | airway trypsin-like protease | Asp | AST | AT | transmembrane protease, serine 11d | transmembrane protease | transmembrane protease, serine 11D
Database Links Click here for help
Specialist databases
MEROPS S01.047 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
inhibitor 1 [Colombo et al., 2012] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.1 pKi 1
pKi 8.1 (Ki 8.4x10-9 M) [1]
compound 5 [PMID: 21741839] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 1.9x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Barrier integrity


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1. Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and synthesis of potent, selective inhibitors of matriptase. ACS Med Chem Lett, 3 (7): 530-4. [PMID:24900505]

2. Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett, 21 (16): 4860-4. [PMID:21741839]

How to cite this page

S1: Chymotrypsin: transmembrane serine protease 11D. Last modified on 27/02/2018. Accessed on 02/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY,