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kallikrein related peptidase 8

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Target not currently curated in GtoImmuPdb

Target id: 2378

Nomenclature: kallikrein related peptidase 8

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 260 19q13.41 KLK8 kallikrein related peptidase 8
Mouse - 260 7 28.26 cM Klk8 kallikrein related-peptidase 8
Rat - 260 1q22 Klk8 kallikrein related-peptidase 8
Previous and Unofficial Names Click here for help
brain serine protease 1 | bsp1 | HNP | kallikrein 8 | neuropsin | NP | Nrpn | ovasin | Prss19 | serine protease 19 | TADG14 | kallikrein-related peptidase 8
Database Links Click here for help
Specialist databases
MEROPS S01.244 (Hs)
Other databases
Alphafold O60259 (Hs), Q61955 (Mm), O88780 (Rn)
BRENDA 3.4.21.118
ChEMBL Target CHEMBL4812 (Hs)
Ensembl Gene ENSG00000129455 (Hs), ENSMUSG00000064023 (Mm), ENSRNOG00000018580 (Rn)
Entrez Gene 11202 (Hs), 259277 (Mm), 308565 (Rn)
Human Protein Atlas ENSG00000129455 (Hs)
KEGG Enzyme 3.4.21.118
KEGG Gene hsa:11202 (Hs), mmu:259277 (Mm), rno:308565 (Rn)
OMIM 605644 (Hs)
Pharos O60259 (Hs)
RefSeq Nucleotide NM_144506 (Hs), NM_144507 (Hs), NM_144505 (Hs), NM_007196 (Hs), NM_008940 (Mm), NM_001107509 (Rn)
RefSeq Protein NP_653089 (Hs), NP_653090 (Hs), NP_653088 (Hs), NP_009127 (Hs), NP_032966 (Mm), NP_001100979 (Rn)
UniProtKB O60259 (Hs), Q61955 (Mm), O88780 (Rn)
Wikipedia KLK8 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.118

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 32 [PMID: 31675166] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.7 pIC50 1
⤷ pIC50 6.7 (IC50 2x10-7 M) [1]

References

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1. De Vita E, Smits N, van den Hurk H, Beck EM, Hewitt J, Baillie G, Russell E, Pannifer A, Hamon V, Morrison A et al.. (2020) Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6. ChemMedChem, 15 (1): 79-95. [PMID:31675166]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 8. Last modified on 06/12/2019. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2378.