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kallikrein related peptidase 2

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Target not currently curated in GtoImmuPdb

Target id: 2372

Nomenclature: kallikrein related peptidase 2

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 19q13.33 KLK2 kallikrein related peptidase 2
Previous and Unofficial Names Click here for help
Kallikrein-2 | kallikrein-related peptidase 2
Database Links Click here for help
Specialist databases
MEROPS S01.161 (Hs)
Other databases
Alphafold P20151 (Hs)
BRENDA 3.4.21.35
ChEMBL Target CHEMBL2442 (Hs)
Ensembl Gene ENSG00000167751 (Hs)
Entrez Gene 3817 (Hs)
Human Protein Atlas ENSG00000167751 (Hs)
KEGG Enzyme 3.4.21.35
KEGG Gene hsa:3817 (Hs)
OMIM 147960 (Hs)
Pharos P20151 (Hs)
RefSeq Nucleotide NM_001256080 (Hs), NM_005551 (Hs), NM_001002231 (Hs)
RefSeq Protein NP_005542 (Hs), NP_001243009 (Hs), NP_001002231 (Hs)
UniProtKB P20151 (Hs)
Wikipedia KLK2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.35

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
hK2p01 derivative KLK2 inhibitor Peptide Primary target of this compound Hs Inhibition 5.8 pKi 1
⤷ pKi 5.8 (Ki 1.41x10-6 M) [1]
peptide KLK2b(c1) Peptide Primary target of this compound Hs Inhibition - - 2
⤷ [2]

References

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1. Hekim C, Leinonen J, Närvänen A, Koistinen H, Zhu L, Koivunen E, Väisänen V, Stenman UH. (2006) Novel peptide inhibitors of human kallikrein 2. J Biol Chem, 281 (18): 12555-60. [PMID:16527822]

2. Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman UH, Vepsäläinen J, Närvänen A. (2007) Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors. J Pept Sci, 13 (5): 348-53. [PMID:17436344]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 2. Last modified on 29/01/2016. Accessed on 14/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2372.