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kallikrein related peptidase 2

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Target not currently curated in GtoImmuPdb

Target id: 2372

Nomenclature: kallikrein related peptidase 2

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 19q13.33 KLK2 kallikrein related peptidase 2
Previous and Unofficial Names Click here for help
Kallikrein-2 | kallikrein-related peptidase 2
Database Links Click here for help
Specialist databases
MEROPS S01.161 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.35

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
hK2p01 derivative KLK2 inhibitor Peptide Primary target of this compound Hs Inhibition 5.8 pKi 1
pKi 5.8 (Ki 1.41x10-6 M) [1]
peptide KLK2b(c1) Peptide Primary target of this compound Hs Inhibition - - 2
[2]

References

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1. Hekim C, Leinonen J, Närvänen A, Koistinen H, Zhu L, Koivunen E, Väisänen V, Stenman UH. (2006) Novel peptide inhibitors of human kallikrein 2. J. Biol. Chem., 281 (18): 12555-60. [PMID:16527822]

2. Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman UH, Vepsäläinen J, Närvänen A. (2007) Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors. J. Pept. Sci., 13 (5): 348-53. [PMID:17436344]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 2. Last modified on 29/01/2016. Accessed on 28/02/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2372.