kallikrein related peptidase 2 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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kallikrein related peptidase 2

Target not currently curated in GtoImmuPdb

Target id: 2372

Nomenclature: kallikrein related peptidase 2

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 19q13.33 KLK2 kallikrein related peptidase 2
Previous and Unofficial Names
Kallikrein-2 | kallikrein-related peptidase 2
Database Links
Specialist databases
MEROPS S01.161 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
hK2p01 derivative KLK2 inhibitor Hs Inhibition 5.8 pKi 1
pKi 5.8 (Ki 1.41x10-6 M) [1]
peptide KLK2b(c1) Hs Inhibition - - 2


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1. Hekim C, Leinonen J, Närvänen A, Koistinen H, Zhu L, Koivunen E, Väisänen V, Stenman UH. (2006) Novel peptide inhibitors of human kallikrein 2. J. Biol. Chem., 281 (18): 12555-60. [PMID:16527822]

2. Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman UH, Vepsäläinen J, Närvänen A. (2007) Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors. J. Pept. Sci., 13 (5): 348-53. [PMID:17436344]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 2. Last modified on 29/01/2016. Accessed on 23/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2372.