transmembrane serine protease 2 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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transmembrane serine protease 2

Target not currently curated in GtoImmuPdb

Target id: 2421

Nomenclature: transmembrane serine protease 2

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 492 21q22.3 TMPRSS2 transmembrane serine protease 2
Mouse - 490 16 C2 Tmprss2 transmembrane protease, serine 2
Rat - 490 11q12 Tmprss2 transmembrane serine protease 2
Previous and Unofficial Names
epitheliasin | plasmic transmembrane protein X | PRSS10 | transmembrane protease, serine 2 | transmembrane protease
Database Links
Specialist databases
MEROPS S01.247 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5 [PMID: 21741839] Hs Inhibition 7.7 pKi 1
pKi 7.7 (Ki 2x10-8 M) [1]


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1. Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg. Med. Chem. Lett., 21 (16): 4860-4. [PMID:21741839]

How to cite this page

S1: Chymotrypsin: transmembrane serine protease 2. Last modified on 27/02/2018. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,