camostat   Click here for help

GtoPdb Ligand ID: 6432

Synonyms: ONO-3403
Approved drug
camostat is an approved drug
Compound class: Synthetic organic
Comment: Publications and data are also linked to the camostat mesilate salt (PubChem CID 5284360). There is an active metabolite reported as FOY 251 but this also maps to the mesylate salt (PubChem CID 130394), with the parent compound being PubChem CID 130395

SARS-CoV-2 and COVID-19: Inhibition of TMPRSS2 partially blocks entry of SARS-CoV-2 into Caco-2 cells [1], a result which indicates an opportunity for repurposing this already approved drug for COVID-19. Complete blockade of SARS-CoV-2 entry can be achieved by combined inhibition of TMPRSS2 (by camostat) and the endosomal cysteine proteases cathepsins B and L (by aloxistatin; E-64d). In August 2020 Edinburgh University, the CRUK's Centre for Drug Development and Latus Therapeutics began the Phase 2/3 SPIKE-1 trial (NCT04455815) of camostat in non-hospitalised CoV-2 positive patients, to determine if the drug can reduce the progression of COVID-19 symptoms- access CRUK's trial webpage here.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 137.31
Molecular weight 398.16
XLogP 1.17
No. Lipinski's rules broken 0
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Canonical SMILES CN(C(=O)COC(=O)Cc1ccc(cc1)OC(=O)c1ccc(cc1)N=C(N)N)C
Isomeric SMILES CN(C(=O)COC(=O)Cc1ccc(cc1)OC(=O)c1ccc(cc1)N=C(N)N)C
InChI InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name Click here for help
[4-[2-(2-dimethylamino-2-oxoethoxy)-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate
International Nonproprietary Names Click here for help
INN number INN
5068 camostat
Synonyms Click here for help
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9678726
Reactome Reaction Reactome logo R-HSA-9681514
Other databases
CAS Registry No. 59721-28-7
ChEMBL Ligand CHEMBL590799
DrugCentral Ligand 471
GtoPdb PubChem SID 178103048
PubChem CID 2536
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UniChem Compound Search for chemical match using the InChIKey XASIMHXSUQUHLV-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey XASIMHXSUQUHLV-UHFFFAOYSA-N
Wikipedia Camostat

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Camostat mesylate (links to external site)
Cat. No. 3193