GtoPdb Ligand ID: 6469

Synonyms: 1-L-leucine-2-L-threonine-63-desulfohirudin | Refludan®
lepirudin is an approved drug (FDA (1998))
Comment: Discontinued (not withdrawn). The drug is a recombinant form of hirudin, the salivary anticoagulant found in leeches (see UniProt P01050), but has two amino acid modifications; substitution of Leu1 for Ile and no sulfate group on Tyr63. The PubChem entry linked to above represents the chemical structure of Lepirudin.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: lepirudin

Compound class Peptide or derivative
Approved drug? Yes (FDA (1998))
International Nonproprietary Names
INN number INN
7355 lepirudin
1-L-leucine-2-L-threonine-63-desulfohirudin | Refludan®
Database Links
CAS Registry No. 138068-37-8 (source: PubChem)
ChEMBL Ligand CHEMBL1201666
DrugBank Ligand DB00001
GtoPdb PubChem SID 178103083
PubChem CID 16132441
Search PubMed clinical trials lepirudin
Search PubMed titles lepirudin
Search PubMed titles/abstracts lepirudin
Wikipedia Lepirudin