lepirudin   Click here for help

GtoPdb Ligand ID: 6469

Synonyms: 1-L-leucine-2-L-threonine-63-desulfohirudin | Refludan®
Approved drug
lepirudin is an approved drug (FDA (1998))
Comment: Discontinued (not withdrawn). The drug is a recombinant form of hirudin, the salivary anticoagulant found in leeches (see UniProt P01050), but has two amino acid modifications; substitution of Leu1 for Ile and no sulfate group on Tyr63. The PubChem entry linked to above represents the chemical structure of Lepirudin.
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Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (FDA (1998))
International Nonproprietary Names Click here for help
INN number INN
7355 lepirudin
Synonyms Click here for help
1-L-leucine-2-L-threonine-63-desulfohirudin | Refludan®
Database Links Click here for help
CAS Registry No. 138068-37-8 (source: PubChem)
ChEMBL Ligand CHEMBL1201666
DrugBank Ligand DB00001
GtoPdb PubChem SID 178103083
PubChem CID 16132441
Search PubMed clinical trials lepirudin
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Wikipedia Lepirudin