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Synonyms: 1-L-leucine-2-L-threonine-63-desulfohirudin | Refludan®
lepirudin is an approved drug (FDA (1998))
Compound class: Peptide or derivative
Comment: Discontinued (not withdrawn). The drug is a recombinant form of hirudin, the salivary anticoagulant found in leeches (see UniProt P01050), but has two amino acid modifications; substitution of Leu1 for Ile and no sulfate group on Tyr63. The PubChem entry linked to above represents the chemical structure of Lepirudin.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: lepirudin
1. Seidel H, Kolde HJ. (2018)
Monitoring of Argatroban and Lepirudin: What is the Input of Laboratory Values in "Real Life"?.
Clin Appl Thromb Hemost, 24 (2): 287-294. [PMID:28320219]
2. Warkentin TE, Greinacher A, Craven S, Dewar L, Sheppard JA, Ofosu FA. (2005)
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation.
Thromb Haemost, 94 (5): 958-64. [PMID:16363236]