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serine protease 8

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Target not currently curated in GtoImmuPdb

Target id: 2400

Nomenclature: serine protease 8

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 343 16p11.2 PRSS8 serine protease 8
Mouse 1 342 7 69.84 cM Prss8 protease, serine 8 (prostasin)
Rat 1 342 1q37 Prss8 serine protease 8
Previous and Unofficial Names Click here for help
CAP1 | channel activating protease 1 | prostasin | protease | protease, serine 8 | protease, serine, 8 (prostasin) | protease, serine 8 (prostasin)
Database Links Click here for help
Specialist databases
MEROPS S01.159 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
B3C Small molecule or natural product Primary target of this compound Hs Inhibition 7.9 pKi 1
pKi 7.9 (Ki 1.2x10-8 M) [1]

References

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1. Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A et al.. (2008) Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg. Med. Chem. Lett., 18 (22): 5895-9. [PMID:18752942]

How to cite this page

S1: Chymotrypsin: serine protease 8. Last modified on 27/02/2018. Accessed on 28/02/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2400.