serine protease 8 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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serine protease 8

Target not currently curated in GtoImmuPdb

Target id: 2400

Nomenclature: serine protease 8

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 343 16p11.2 PRSS8 serine protease 8
Mouse - 341 7 F3 Prss8 protease, serine 8 (prostasin)
Rat - 342 1q36 Prss8 serine protease 8
Previous and Unofficial Names
CAP1 | channel activating protease 1 | prostasin | protease, serine, 8 (prostasin) | protease | protease, serine 8 (prostasin) | protease, serine 8
Database Links
Specialist databases
MEROPS S01.159 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
B3C Hs Inhibition 7.9 pKi 1
pKi 7.9 (Ki 1.2x10-8 M) [1]


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1. Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A et al.. (2008) Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg. Med. Chem. Lett., 18 (22): 5895-9. [PMID:18752942]

How to cite this page

S1: Chymotrypsin: serine protease 8. Last modified on 27/02/2018. Accessed on 23/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,