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coagulation factor XII

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Target not currently curated in GtoImmuPdb

Target id: 2361

Nomenclature: coagulation factor XII

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 615 5q35.3 F12 coagulation factor XII
Mouse - 597 13 B1 F12 coagulation factor XII (Hageman factor)
Rat - 595 17p14 F12 coagulation factor XII
Previous and Unofficial Names Click here for help
factor XII | FXII | HAF | hageman factor | coagulation factor XII (Hageman factor)
Database Links Click here for help
Specialist databases
MEROPS S01.211 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate Small molecule or natural product Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1.04x10-8 M) [1]
Inhibitor Comments
Factor XIIa blocking antibody 3F7 is an inhibitor of FXIIa.
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
anti-FXII nanobody N4-38 Peptide Hs Binding 8.5 pKd 2
pKd 8.5 (Kd 3.07x10-9 M) [2]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Angioedema, hereditary, type III; HAE3
Synonyms: Hereditary angioedema [Disease Ontology: DOID:14735]
Hereditary angioedema type 3 [Orphanet: ORPHA100054]
Disease Ontology: DOID:14735
OMIM: 610618
Orphanet: ORPHA100054
Disease:  Factor XII deficiency
Disease Ontology: DOID:2231
OMIM: 234000
Orphanet: ORPHA330


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1. Diamond SL. Factor XIIa 1536 HTS Dose Response Confirmation - BioAssay Summary. Accessed on 06/09/2013. Modified on 06/09/2013. PubChem,

2. Wang M, Xu P. (2021) Anti-fxii nanobody or antigen binding fragment thereof and use thereof. Patent number: WO2021253662A1. Assignee: Ningbo Kangshan Biotechnology Co., Ltd.. Priority date: 21/09/2020. Publication date: 23/12/2021.

How to cite this page

S1: Chymotrypsin: coagulation factor XII. Last modified on 21/03/2024. Accessed on 24/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,