coagulation factor XII | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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coagulation factor XII

Target not currently curated in GtoImmuPdb

Target id: 2361

Nomenclature: coagulation factor XII

Family: S1: Chymotrypsin

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 615 5q33-qter F12 coagulation factor XII
Mouse - 597 13 B2 F12 coagulation factor XII (Hageman factor)
Rat - 595 17p14 F12 coagulation factor XII
Previous and Unofficial Names
factor XII | FXII | HAF | hageman factor | coagulation factor XII (Hageman factor)
Database Links
Specialist databases
MEROPS S01.211 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1.04x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002353 plasma kallikrein-kinin cascade IDA
GO:0002542 Factor XII activation IDA
GO:0045087 innate immune response TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002542 Factor XII activation IDA
Clinically-Relevant Mutations and Pathophysiology
Disease:  Angioedema, hereditary, type III; HAE3
Synonyms: Hereditary angioedema [Disease Ontology: DOID:14735]
Hereditary angioedema type 3 [Orphanet: ORPHA100054]
Disease Ontology: DOID:14735
OMIM: 610618
Orphanet: ORPHA100054
Disease:  Factor XII deficiency
Disease Ontology: DOID:2231
OMIM: 234000
Orphanet: ORPHA330


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1. Diamond SL. Factor XIIa 1536 HTS Dose Response Confirmation - BioAssay Summary. Accessed on 06/09/2013. Modified on 06/09/2013. PubChem,

How to cite this page

S1: Chymotrypsin: coagulation factor XII. Last modified on 29/01/2016. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,