Top ▲
Gene and Protein Information ![]() |
||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 253 | 19q13.41 | KLK7 | kallikrein related peptidase 7 | |
Mouse | - | 249 | 7 28.27 cM | Klk7 | kallikrein related-peptidase 7 (chymotryptic, stratum corneum) | |
Rat | - | 261 | 1q22 | Klk7 | kallikrein-related peptidase 7 |
Previous and Unofficial Names ![]() |
kallikrein-7 | protease, serine, 6 | Prss6 | SCCE | serine protease 6 | thymopsin | kallikrein related-peptidase 7 (chymotryptic |
Database Links ![]() |
|
Specialist databases | |
MEROPS | S01.300 (Hs) |
Other databases | |
Alphafold | P49862 (Hs), Q91VE3 (Mm), P36373 (Rn) |
BRENDA | 3.4.21.117 |
ChEMBL Target | CHEMBL2443 (Hs), CHEMBL4295910 (Mm) |
Ensembl Gene | ENSG00000169035 (Hs), ENSMUSG00000030713 (Mm), ENSRNOG00000018664 (Rn) |
Entrez Gene | 5650 (Hs), 23993 (Mm), 292852 (Rn) |
Human Protein Atlas | ENSG00000169035 (Hs) |
KEGG Enzyme | 3.4.21.117 |
KEGG Gene | hsa:5650 (Hs), mmu:23993 (Mm), rno:292852 (Rn) |
OMIM | 604438 (Hs) |
Pharos | P49862 (Hs) |
RefSeq Nucleotide | NM_001207053 (Hs), NM_001243126 (Hs), NM_005046 (Hs), NM_139277 (Hs), NM_011872 (Mm), NM_012593 (Rn) |
RefSeq Protein | NP_644806 (Hs), NP_005037 (Hs), NP_001230055 (Hs), NP_001193982 (Hs), NP_036002 (Mm), NP_036725 (Rn) |
UniProtKB | P49862 (Hs), Q91VE3 (Mm), P36373 (Rn) |
Wikipedia | KLK7 (Hs) |
Enzyme Reaction ![]() |
||||
|
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Immuno Process Associations | ||
|
1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett, 23 (16): 4547-51. [PMID:23849879]
2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem, 58 (2): 598-612. [PMID:25489658]
S1: Chymotrypsin: kallikrein related peptidase 7. Last modified on 29/01/2016. Accessed on 14/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2377.