TFC007 [Ligand Id: 11392] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4238186 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| H-PGDS/Hematopoietic prostaglandin D synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760] | ||||||||
| ChEMBL | Binding affinity to full length recombinant human N-terminal His6-tagged H-PGDS expressed in Escherichia coli BL21(DE3) by SPR analysis | B | 9.43 | pKd | 0.37 | nM | Kd | Bioorg Med Chem (2018) 26: 4726-4734 [PMID:30121213] |
| ChEMBL | Binding affinity to recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence polarization assay | B | 6.49 | pIC50 | 320 | nM | IC50 | ACS Med Chem Lett (2021) 12: 236-241 [PMID:33603969] |
| ChEMBL | Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assay | B | 6.77 | pIC50 | 170 | nM | IC50 | J Med Chem (2021) 64: 15868-15882 [PMID:34652145] |
| GtoPdb | - | - | 7.08 | pIC50 | - | - | - | Prostaglandins Other Lipid Mediat (2011) 95: 27-34 [PMID:21601002] |
| ChEMBL | Inhibition of recombinant human HPGDS using [14C]-PGH2 as substrate preincubated for 1 min in presence of MgCl2 followed by substrate addition and measured after 45 mins by radioactive imaging analysis | B | 7.08 | pIC50 | 83 | nM | IC50 | ACS Med Chem Lett (2021) 12: 236-241 [PMID:33603969] |
| ChEMBL | Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysis | B | 7.15 | pIC50 | 71 | nM | IC50 | ACS Med Chem Lett (2021) 12: 236-241 [PMID:33603969] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
