ivabradine [Ligand Id: 2357] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL471737 (Ivabradine, S-16257, Corlanor, Procoralan)
  • HCN1 in Human [GtoPdb: 400] [UniProtKB: O60741]
  • HCN1/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 in Mouse [ChEMBL: CHEMBL1250401] [GtoPdb: 400] [UniProtKB: O88704]
  • This target only has 0 pki data point
  • 0
1 CHEMBL471737_lig_chart_1 HCN1 HumanMouse
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  • HCN2/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 in Mouse [ChEMBL: CHEMBL1250408] [GtoPdb: 401] [UniProtKB: O88703]
  • This target only has 0 pki data point
  • 0
2 CHEMBL471737_lig_chart_2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Mouse
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  • HCN4/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 in Human [ChEMBL: CHEMBL1250417] [GtoPdb: 403] [UniProtKB: Q9Y3Q4]
  • This target only has 0 pki data point
  • 0
3 CHEMBL471737_lig_chart_3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Human
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  • HCN3 in Human [GtoPdb: 402] [UniProtKB: Q9P1Z3]
  • This target only has 0 pki data point
  • 0
4 CHEMBL471737_lig_chart_4 HCN3 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCN1 in Human [GtoPdb: 400] [UniProtKB: O60741]
GtoPdb - - 5.7 pIC50 2250 nM IC50 Mol Pharmacol (2006) 69: 1328-37 [PMID:16387796]
HCN1/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250401] [GtoPdb: 400] [UniProtKB: O88704]
GtoPdb - - 6 pIC50 - - - J Physiol (Lond.) (2006) 572: 335-46 [PMID:16484306]
ChEMBL Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay B 5.35 pEC50 4500 nM EC50 J. Med. Chem. (2010) 53: 6773-6777 [PMID:20795648]
HCN2/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250408] [GtoPdb: 401] [UniProtKB: O88703]
GtoPdb - - 5.6 pIC50 2290 nM IC50 Mol Pharmacol (2006) 69: 1328-37 [PMID:16387796]
ChEMBL Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay B 5.34 pEC50 4520 nM EC50 J. Med. Chem. (2010) 53: 6773-6777 [PMID:20795648]
HCN4/Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250417] [GtoPdb: 403] [UniProtKB: Q9Y3Q4]
GtoPdb - - 5.7 pIC50 2250 nM IC50 Mol Pharmacol (2006) 69: 1328-37 [PMID:16387796]
ChEMBL Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay B 5.37 pEC50 4280 nM EC50 J. Med. Chem. (2010) 53: 6773-6777 [PMID:20795648]
HCN3 in Human [GtoPdb: 402] [UniProtKB: Q9P1Z3]
GtoPdb - - 5.7 pIC50 2250 nM IC50 Mol Pharmacol (2006) 69: 1328-37 [PMID:16387796]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]