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Gene and Protein Information | |||||||
Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 6 | 1 | 889 | 19p13.3 | HCN2 | hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 | 35 |
Mouse | 6 | 1 | 863 | 10 C1 | Hcn2 | hyperpolarization-activated, cyclic nucleotide-gated K+ 2 | 34,51 |
Rat | 6 | 1 | 863 | 7q11 | Hcn2 | hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 | 40 |
Database Links | |
Alphafold | Q9UL51 (Hs), O88703 (Mm), Q9JKA9 (Rn) |
CATH/Gene3D | 2.60.120.10 |
ChEMBL Target | CHEMBL1795172 (Hs), CHEMBL1250408 (Mm) |
Ensembl Gene | ENSG00000099822 (Hs), ENSMUSG00000020331 (Mm), ENSRNOG00000008831 (Rn) |
Entrez Gene | 610 (Hs), 15166 (Mm), 114244 (Rn) |
Human Protein Atlas | ENSG00000099822 (Hs) |
KEGG Gene | hsa:610 (Hs), mmu:15166 (Mm), rno:114244 (Rn) |
OMIM | 602781 (Hs) |
Pharos | Q9UL51 (Hs) |
RefSeq Nucleotide | NM_001194 (Hs), NM_008226 (Mm), NM_053684 (Rn) |
RefSeq Protein | NP_001185 (Hs), NP_032252 (Mm), NP_446136 (Rn) |
SynPHARM |
5504 (in complex with cyclic AMP) 5505 (in complex with cyclic GMP) |
UniProtKB | Q9UL51 (Hs), O88703 (Mm), Q9JKA9 (Rn) |
Wikipedia | HCN2 (Hs) |
Associated Proteins | ||||||||||||||||||||||||||||||||
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Ion Selectivity and Conductance | ||||||
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Voltage Dependence | ||||||||||||||||||||||
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Activators (Human) |
cyclic AMP > cyclic GMP |
Download all structure-activity data for this target as a CSV file
Activators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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cAMP and cGMP shift V0.5 by +10 to +20 mV [34-35,50,60]. |
Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Propofol inhibits and slows activation of the mouse HCN2 channel at clinically relevant concentrations [4]. |
Immuno Process Associations | ||
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2. Brandt MC, Endres-Becker J, Zagidullin N, Motloch LJ, Er F, Rottlaender D, Michels G, Herzig S, Hoppe UC. (2009) Effects of KCNE2 on HCN isoforms: distinct modulation of membrane expression and single channel properties. Am J Physiol Heart Circ Physiol, 297 (1): H355-63. [PMID:19429827]
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4. Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. (2005) Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther, 315 (2): 517-25. [PMID:16033909]
5. Cao-Ehlker X, Zong X, Hammelmann V, Gruner C, Fenske S, Michalakis S, Wahl-Schott C, Biel M. (2013) Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). J Biol Chem, 288 (11): 7580-9. [PMID:23382386]
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24. Horwitz GC, Risner-Janiczek JR, Jones SM, Holt JR. (2011) HCN channels expressed in the inner ear are necessary for normal balance function. J Neurosci, 31 (46): 16814-25. [PMID:22090507]
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28. Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. (2007) Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation, 115 (7): 872-80. [PMID:17261653]
29. Koch U, Braun M, Kapfer C, Grothe B. (2004) Distribution of HCN1 and HCN2 in rat auditory brainstem nuclei. Eur J Neurosci, 20 (1): 79-91. [PMID:15245481]
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31. Lin YC, Huang J, Zhang Q, Hollander JM, Frisbee JC, Martin KH, Nestor C, Goodman R, Yu HG. (2010) Inactivation of L-type calcium channel modulated by HCN2 channel. Am J Physiol, Cell Physiol, 298 (5): C1029-37. [PMID:20164379]
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49. Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG. (2012) HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. J Biol Chem, 287 (45): 37628-46. [PMID:22948144]
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62. Xia S, Wang Y, Zhang Y, Deng SB, Du JL, Wang XC, She Q. (2010) Dynamic changes in HCN2, HCN4, KCNE1, and KCNE2 expression in ventricular cells from acute myocardial infarction rat hearts. Biochem Biophys Res Commun, 395 (3): 330-5. [PMID:20381460]
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64. Ying SW, Jia F, Abbas SY, Hofmann F, Ludwig A, Goldstein PA. (2007) Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons. J Neurosci, 27 (32): 8719-32. [PMID:17687049]
65. Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA. (2012) Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS ONE, 7 (8): e42756. [PMID:22880098]
66. Yu X, Chen XW, Zhou P, Yao L, Liu T, Zhang B, Li Y, Zheng H, Zheng LH, Zhang CX et al.. (2007) Calcium influx through If channels in rat ventricular myocytes. Am J Physiol, Cell Physiol, 292 (3): C1147-55. [PMID:17065201]
67. Zhang Y, Liu Y, Qu J, Hardy A, Zhang N, Diao J, Strijbos PJ, Tsushima R, Robinson RB, Gaisano HY et al.. (2009) Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells. J Endocrinol, 203 (1): 45-53. [PMID:19654142]
68. Zong X, Eckert C, Yuan H, Wahl-Schott C, Abicht H, Fang L, Li R, Mistrik P, Gerstner A, Much B et al.. (2005) A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase. J Biol Chem, 280 (40): 34224-32. [PMID:16079136]
69. Zong X, Krause S, Chen CC, Krüger J, Gruner C, Cao-Ehlker X, Fenske S, Wahl-Schott C, Biel M. (2012) Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP. J Biol Chem, 287 (32): 26506-12. [PMID:22715094]