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Voltage-gated ion channels C


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The voltage-gated ion channels and their structural relatives comprise a superfamily encoded by at least 143 genes in the human genome and are therefore one of the largest superfamilies of signal transduction proteins, following the G protein-coupled receptors and the protein kinases in number [1]. In addition to their prominence in signal transduction, these ion channels are also among the most common drug targets. As for other large protein superfamilies, understanding the molecular relationships among family members, developing a unified, rational nomenclature for the ion channel families and subfamilies, and assigning physiological functions and pharmacological significance to each family member has been an important challenge. Some of the ion channels placed under the 'Voltage-gated' umbrella are not in fact gated by voltage, but for the reasons mention above it is useful to consider them within this superfamily. The Inwardly rectifying potassium channels, Two P domain potassium channels, ryanodine receptors and transient receptor potential channels are those that are NOT voltage-gated.


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How to cite this family page

Database page citation:

Voltage-gated ion channels. Accessed on 07/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. Br J Pharmacol. 176 Issue S1: S142-228.