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Voltage-gated potassium channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.

Channels and Subunits

Kv1.1 C Show summary » More detailed page

Kv1.2 C Show summary » More detailed page

Kv1.3 C Show summary » More detailed page

Kv1.4 C Show summary » More detailed page

Kv1.5 C Show summary » More detailed page

Kv1.6 C Show summary » More detailed page

Kv1.7 C Show summary » More detailed page

Kv1.8 C Show summary » More detailed page

Kv2.1 C Show summary » More detailed page

Kv2.2 C Show summary » More detailed page

Kv3.1 C Show summary » More detailed page

Kv3.2 C Show summary » More detailed page

Kv3.3 C Show summary » More detailed page

Kv3.4 C Show summary » More detailed page

Kv4.1 C Show summary » More detailed page

Kv4.2 C Show summary » More detailed page

Kv4.3 C Show summary » More detailed page

Kv5.1 C Show summary » More detailed page

Kv6.1 C Show summary » More detailed page

Kv6.2 C Show summary » More detailed page

Kv6.3 C Show summary » More detailed page

Kv6.4 C Show summary » More detailed page

Kv7.1 C Show summary » More detailed page

Kv7.2 C Show summary » More detailed page

Kv7.3 C Show summary » More detailed page

Kv7.4 C Show summary » More detailed page

Kv7.5 C Show summary » More detailed page

Kv8.1 C Show summary » More detailed page

Kv8.2 C Show summary » More detailed page

Kv9.1 C Show summary » More detailed page

Kv9.2 C Show summary » More detailed page

Kv9.3 C Show summary » More detailed page

Kv10.1 C Show summary » More detailed page

Kv10.2 C Show summary » More detailed page

Kv11.1 C Show summary » More detailed page

Kv11.2 C Show summary » More detailed page

Kv11.3 C Show summary » More detailed page

Kv12.1 C Show summary » More detailed page

Kv12.2 C Show summary » More detailed page

Kv12.3 C Show summary » More detailed page

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. Br J Pharmacol. 176 Issue S1: S142-228.