Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	0	466	18q23	KCNG2	potassium voltage-gated channel modifier subfamily G member 2	5
Mouse	6	0	480	18 E3	Kcng2	potassium voltage-gated channel, subfamily G, member 2
Rat	6	0	480	18q12.3	Kcng2	potassium voltage-gated channel modifier subfamily G member 2

Previous and Unofficial Names

KCNF2 | KCNG2 | cardiac potassium channel subunit (Kv6.2) | potassium channel, voltage gated modifier subfamily G, member 2 | potassium voltage-gated channel

Database Links
Alphafold	Q9UJ96 (Hs), Q9QYU3 (Rn)
Ensembl Gene	ENSG00000178342 (Hs), ENSMUSG00000059852 (Mm), ENSRNOG00000053640 (Rn)
Entrez Gene	26251 (Hs), 240444 (Mm), 307234 (Rn)
Human Protein Atlas	ENSG00000178342 (Hs)
KEGG Gene	hsa:26251 (Hs), mmu:240444 (Mm), rno:307234 (Rn)
OMIM	605696 (Hs)
Pharos	Q9UJ96 (Hs)
RefSeq Nucleotide	NM_012283 (Hs), NM_001190373 (Mm), NM_001107372 (Rn)
RefSeq Protein	NP_036415 (Hs), NP_001177302 (Mm), NP_001100842 (Rn)
UniProtKB	Q9UJ96 (Hs), Q9QYU3 (Rn)
Wikipedia	KCNG2 (Hs)

Associated Proteins
Heteromeric Pore-forming Subunits Name References Kv2.1 5	Auxiliary Subunits Name References Not determined	Other Associated Proteins Name References Not determined

Ion Selectivity and Conductance
Species:  None Macroscopic current rectification:  Modifiers/ Silencer References:

Tissue Distribution
Myocardium, fetal brain, germinal center B-cells Species:  Human Technique:  In situ hybridisation References:  5
Pancreatic β cell Species:  Human Technique:  In situ hybridisation References:  4
Pulmonary artery smooth muscle cell (PASMC) Species:  Human Technique:  RT-PCR References:  1-2
Urinary bladder smooth muscle (UBSM) myocyte Species:  Mouse Technique:  RT-PCR References:  3

Functional Assays

Molecular clone, patch clamp and yeast two-hybrid Species:  Human Tissue:  Myocardium cDNA exprsssed in Xenopus laevis oocytes Response measured:  Formation of heteromultimeric Kv channels with Kv2.1 α subunits. Kv2.1/Kv6.2 channels have submicromolar sensitivity to the antiarrhythmic drug propafenone. Suggests that delayed-rectifier type channels containing Kv6.2 subunits may contribute to cardiac action potential repolarization. References:  5

Physiological Functions
Modifier / silencer, co-assembles with Kv2.1 producing K+ channels with unique properties. Species:  Human Tissue:  Myocardium cDNA exprsssed in Xenopus laevis oocytes References:  5

Gene Expression and Pathophysiology
Ten-fold decrease of Kv6.2 mRNA expression in pulmonary artery smooth cells induced by Bone Morphogenetic Protein-2 (BMP-2) Tissue or cell type:  Pulmonary artery smooth muscle cells (PASMC) Pathophysiology:  Proliferation inhibition and apoptosis in normal human PASMC induced by BMP's Species:  Human Technique:  RT-PCR References:  1

Biologically Significant Variants
Type:  Splice variant Species:  Human Description:  Modifier / silencer, co-assembles with Kv2.1 producing K+ channels with unique properties Amino acids:  466 Nucleotide accession:  NM_012283 Protein accession:  NP_036415 References:  5
Biologically Significant Variant Comments
A total of 1190 SNPs have been identified in human KCNG2. For more information please see the entry on GeneCards.

General Comments
Kv6.2 has no function on its own, but plays a role in modulation of Kv2 channels.