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Kv6.2

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Target not currently curated in GtoImmuPdb

Target id: 557

Nomenclature: Kv6.2

Family: Voltage-gated potassium channels

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 0 466 18q23 KCNG2 potassium voltage-gated channel modifier subfamily G member 2 5
Mouse 6 0 480 18 E3 Kcng2 potassium voltage-gated channel, subfamily G, member 2
Rat 6 0 480 18q12.3 Kcng2 potassium voltage-gated channel modifier subfamily G member 2
Previous and Unofficial Names Click here for help
KCNF2 | KCNG2 | cardiac potassium channel subunit (Kv6.2) | potassium channel, voltage gated modifier subfamily G, member 2 | potassium voltage-gated channel
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins Click here for help
Heteromeric Pore-forming Subunits
Name References
Kv2.1 5
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Ion Selectivity and Conductance Click here for help
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Tissue Distribution Click here for help
Myocardium, fetal brain, germinal center B-cells
Species:  Human
Technique:  In situ hybridisation
References:  5
Pancreatic β cell
Species:  Human
Technique:  In situ hybridisation
References:  4
Pulmonary artery smooth muscle cell (PASMC)
Species:  Human
Technique:  RT-PCR
References:  1-2
Urinary bladder smooth muscle (UBSM) myocyte
Species:  Mouse
Technique:  RT-PCR
References:  3
Functional Assays Click here for help
Molecular clone, patch clamp and yeast two-hybrid
Species:  Human
Tissue:  Myocardium cDNA exprsssed in Xenopus laevis oocytes
Response measured:  Formation of heteromultimeric Kv channels with Kv2.1 α subunits.
Kv2.1/Kv6.2 channels have submicromolar sensitivity to the antiarrhythmic drug propafenone. Suggests that delayed-rectifier type channels containing Kv6.2 subunits may contribute to cardiac action potential repolarization.
References:  5
Physiological Functions Click here for help
Modifier / silencer, co-assembles with Kv2.1 producing K+ channels with unique properties.
Species:  Human
Tissue:  Myocardium cDNA exprsssed in Xenopus laevis oocytes
References:  5
Gene Expression and Pathophysiology Click here for help
Ten-fold decrease of Kv6.2 mRNA expression in pulmonary artery smooth cells induced by Bone Morphogenetic Protein-2 (BMP-2)
Tissue or cell type:  Pulmonary artery smooth muscle cells (PASMC)
Pathophysiology:  Proliferation inhibition and apoptosis in normal human PASMC induced by BMP's
Species:  Human
Technique:  RT-PCR
References:  1
Biologically Significant Variants Click here for help
Type:  Splice variant
Species:  Human
Description:  Modifier / silencer, co-assembles with Kv2.1 producing K+ channels with unique properties
Amino acids:  466
Nucleotide accession: 
Protein accession: 
References:  5
Biologically Significant Variant Comments
A total of 1190 SNPs have been identified in human KCNG2. For more information please see the entry on GeneCards.
General Comments
Kv6.2 has no function on its own, but plays a role in modulation of Kv2 channels.

References

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1. Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. (2006) Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 291 (5): L993-1004. [PMID:16815889]

2. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. (2004) Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 287 (1): L226-38. [PMID:15047570]

3. Thorneloe KS, Nelson MT. (2003) Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J Physiol (Lond.), 549 (Pt 1): 65-74. [PMID:12679374]

4. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. (2004) Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes, 53 (3): 597-607. [PMID:14988243]

5. Zhu XR, Netzer R, Böhlke K, Liu Q, Pongs O. (1999) Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel. Recept Channels, 6 (5): 337-50. [PMID:10551266]

Contributors

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