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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 491 | 2p24.2 | KCNS3 | potassium voltage-gated channel modifier subfamily S member 3 | |
| Mouse | 6 | 1 | 491 | 12 5.58 cM | Kcns3 | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | |
| Rat | 6 | 1 | 491 | 6q15 | Kcns3 | potassium voltage-gated channel, modifier subfamily S, member 3 | |
| Previous and Unofficial Names |
| delayed-rectifier K(+) channel alpha subunit 3 | voltage-gated potassium channel subunit Kv9.3 | potassium voltage-gated channel, modifier subfamily S, member 3 | potassium voltage-gated channel |
| Database Links |
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| Alphafold | Q9BQ31 (Hs), Q8BQZ8 (Mm), O88759 (Rn) |
| Ensembl Gene | ENSG00000170745 (Hs), ENSMUSG00000043673 (Mm), ENSRNOG00000004899 (Rn) |
| Entrez Gene | 3790 (Hs), 238076 (Mm), 83588 (Rn) |
| Human Protein Atlas | ENSG00000170745 (Hs) |
| KEGG Gene | hsa:3790 (Hs), mmu:238076 (Mm), rno:83588 (Rn) |
| OMIM | 603888 (Hs) |
| Pharos | Q9BQ31 (Hs) |
| RefSeq Nucleotide | NM_002252 (Hs), NM_173417 (Mm), NM_031778 (Rn) |
| RefSeq Protein | NP_002243 (Hs), NP_775593 (Mm), NP_113966 (Rn) |
| UniProtKB | Q9BQ31 (Hs), Q8BQZ8 (Mm), O88759 (Rn) |
| Wikipedia | KCNS3 (Hs) |
| Ion Selectivity and Conductance |
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| Activator Comments | ||
| Kv9.3 / Kv2.1 form ATP-dependent delayed rectifier channels in oxygen-sensitive pulmonary myocytes. Hypoxia blocks Kv9.3 / Kv2.1 channels [1-5] |
| Gating Inhibitor Comments | ||
| Kv9.3 / Kv2.1 heteromers inactivate in a fast and complete fashion from intermediate closed states but in a slow and incomplete manner from open states [2] Kv2.1 / Kv9.3 heteromeric channels are inhibited by hypoxia in the voltage range of the PA VSMC EM [1] |
| Tissue Distribution
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| General Comments |
| The human Kv9.3 gene is intronless across the coding region 3'-UTR and all of the analysed 5'-UTR [4] |
1. Hulme JT, Coppock EA, Felipe A, Martens JR, Tamkun MM. (1999) Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Circ Res, 85 (6): 489-97. [PMID:10488051]
2. Kerschensteiner D, Stocker M. (1999) Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation. Biophys J, 77 (1): 248-57. [PMID:10388754]
3. Patel AJ, Lazdunski M, Honoré E. (1999) Kv2.1/Kv9.3, an ATP-dependent delayed-rectifier K+ channel in pulmonary artery myocytes. Ann N Y Acad Sci, 868: 438-41. [PMID:10414317]
4. Shepard AR, Rae JL. (1999) Electrically silent potassium channel subunits from human lens epithelium. Am J Physiol, 277 (3): C412-24. [PMID:10484328]
5. Stocker M, Kerschensteiner D. (1998) Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Biochem Biophys Res Commun, 248 (3): 927-34. [PMID:9704029]
