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Target not currently curated in GtoImmuPdb

Target id: 569

Nomenclature: Kv9.3

Family: Voltage-gated potassium channels (Kv)

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 491 2p24.2 KCNS3 potassium voltage-gated channel modifier subfamily S member 3
Mouse 6 1 491 12 5.58 cM Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
Rat 6 1 491 6q15 Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3
Previous and Unofficial Names Click here for help
delayed-rectifier K(+) channel alpha subunit 3 | voltage-gated potassium channel subunit Kv9.3 | potassium voltage-gated channel, modifier subfamily S, member 3 | potassium voltage-gated channel
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Ion Selectivity and Conductance Click here for help
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
Activator Comments
Kv9.3 / Kv2.1 form ATP-dependent delayed rectifier channels in oxygen-sensitive pulmonary myocytes.
Hypoxia blocks Kv9.3 / Kv2.1 channels [1-5]
Gating Inhibitor Comments
Kv9.3 / Kv2.1 heteromers inactivate in a fast and complete fashion from intermediate closed states but in a slow and incomplete manner from open states [2]
Kv2.1 / Kv9.3 heteromeric channels are inhibited by hypoxia in the voltage range of the PA VSMC EM [1]
Tissue Distribution Click here for help
Heart, brain, spleen, lung, kidney, artery
Species:  Rat
Technique:  Northern Blot
References:  3,5
General Comments
The human Kv9.3 gene is intronless across the coding region 3'-UTR and all of the analysed 5'-UTR [4]


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1. Hulme JT, Coppock EA, Felipe A, Martens JR, Tamkun MM. (1999) Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Circ Res, 85 (6): 489-97. [PMID:10488051]

2. Kerschensteiner D, Stocker M. (1999) Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation. Biophys J, 77 (1): 248-57. [PMID:10388754]

3. Patel AJ, Lazdunski M, Honoré E. (1999) Kv2.1/Kv9.3, an ATP-dependent delayed-rectifier K+ channel in pulmonary artery myocytes. Ann N Y Acad Sci, 868: 438-41. [PMID:10414317]

4. Shepard AR, Rae JL. (1999) Electrically silent potassium channel subunits from human lens epithelium. Am J Physiol, 277 (3): C412-24. [PMID:10484328]

5. Stocker M, Kerschensteiner D. (1998) Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Biochem Biophys Res Commun, 248 (3): 927-34. [PMID:9704029]


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