K<SUB>v</SUB>6.1 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Kv6.1

Target not currently curated in GtoImmuPdb

Target id: 556

Nomenclature: Kv6.1

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 513 20q13 KCNG1 potassium voltage-gated channel modifier subfamily G member 1 8
Mouse 6 1 534 2 H3 Kcng1 potassium voltage-gated channel, subfamily G, member 1
Rat 6 1 514 3q42 Kcng1 potassium voltage-gated channel modifier subfamily G member 1
Previous and Unofficial Names
K13 | KCNG1 | KH2 | potassium channel, voltage gated modifier subfamily G, member 1 | potassium channel, voltage-gated modifier subfamily G, member 1 | potassium voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Kv2.1 3,6-7
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Calmodulin 4
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Tissue Distribution
Cardiac monocytes (sinoatrial node)
Species:  Human
Technique:  In situ hybridisation
References:  1
Skeletal muscle, brain, uterus, ovary, kidney, pancreas, placenta, bone, germ cells, prostate, skin, testis.
Species:  Human
Technique:  Northern blot
References:  8
Pulmonary artery smooth muscle cell (PASMC)
Species:  Human
Technique:  RT-PCR
References:  5
Pancreatic α cell
Species:  Human
Technique:  RT-PCR, In situ hybridisation
References:  12
Urinary bladder smooth muscle (UBSM) myocyte
Species:  Mouse
Technique:  RT-PCR
References:  9
Brain
Species:  Rat
Technique:  In situ hybridisation
References:  2,10
Pituitary
Species:  Rat
Technique:  RT-PCR
References:  11
Functional Assays
Molecular cloning, two microelectrode voltage clamp and yeast two-hybrid. The same response was also seen in rats.
Species:  Mouse
Tissue:  Brain-derived cDNAs expressed in Xenopus laevis oocytes
Response measured:  Protein-protein interactions between Kv2.1 and electrically silent Kv6.1 α-subunits detected.
Novel current with decreased rates of deactivation, and a hyperpolarizing shift of half maximal activation potential when compared to Kv2.1.
References:  3,6-7
Physiological Functions
Kv6.1 subunits, when expressed alone, are unable to elicit any current. However, Kv6.1 can suppress Kv2.1 current (albeit less effectively than Kv5.1) and to a lesser extent, it can suppress Kv2.2.
The Kv2.1 currents are strongly modified by Kv6.1, which increases the time constant of activation and slows down inactivation.
Species:  Human
Tissue:  Heterologous Xenopus laevis oocytes
References:  3,6-7
Biologically Significant Variant Comments
A total of 457 SNPs have been identified in human KCNG1. Please see the entry on GeneCards for more information.

This variant has questionable validity because it originates from a cancer cell line
  • RNA sequence: NM_172318.2
  • Protein sequence: NP_758529.1
  • Amino acids: 275
  • Type: Splice variant
  • Species: Human
  • [63,67,240]
.
General Comments
Kv6.1 has no function on its own, but has modulatory actions on Kv2 channels.

References

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1. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, Strauss HC. (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ. Res., 78 (6): 1083-9. [PMID:8635239]

2. Drewe JA, Verma S, Frech G, Joho RH. (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J. Neurosci., 12 (2): 538-48. [PMID:1740690]

3. Kramer JW, Post MA, Brown AM, Kirsch GE. (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Am. J. Physiol., 274 (6 Pt 1): C1501-10. [PMID:9696692]

4. O'Connell DJ, Bauer MC, O'Brien J, Johnson WM, Divizio CA, O'Kane SL, Berggård T, Merino A, Akerfeldt KS, Linse S et al.. (2010) Integrated protein array screening and high throughput validation of 70 novel neural calmodulin-binding proteins. Mol. Cell Proteomics, 9 (6): 1118-32. [PMID:20068228]

5. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. (2004) Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol., 287 (1): L226-38. [PMID:15047570]

6. Post MA, Kirsch GE, Brown AM. (1996) Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. FEBS Lett., 399 (1-2): 177-82. [PMID:8980147]

7. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J. Biol. Chem., 272 (39): 24371-9. [PMID:9305895]

8. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y. (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem. Biophys. Res. Commun., 241 (3): 675-81. [PMID:9434767]

9. Thorneloe KS, Nelson MT. (2003) Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J. Physiol. (Lond.), 549 (Pt 1): 65-74. [PMID:12679374]

10. Verma-Kurvari S, Border B, Joho RH. (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res. Mol. Brain Res., 46 (1-2): 54-62. [PMID:9191078]

11. Wulfsen I, Hauber HP, Schiemann D, Bauer CK, Schwarz JR. (2000) Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. J. Neuroendocrinol., 12 (3): 263-72. [PMID:10718922]

12. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. (2004) Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes, 53 (3): 597-607. [PMID:14988243]

Contributors

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