Top ▲
Gene and Protein Information  |
|||||||
| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 994 | 17q23.3 | KCNH6 | potassium voltage-gated channel subfamily H member 6 | |
| Mouse | 6 | 1 | 950 | 11 E1 | Kcnh6 | potassium voltage-gated channel, subfamily H (eag-related), member 6 | |
| Rat | 6 | 1 | 950 | 10q32.1 | Kcnh6 | potassium voltage-gated channel subfamily H member 6 | |
| Previous and Unofficial Names |
| erg2 | HERG2 | eag-related protein 2 | ether-a-go-go-related gene potassium channel 2 | ether-a-go-go-related protein 2 | potassium voltage-gated channel, subfamily H (eag-related), member 6 | potassium channel, voltage gated eag related subfamily H, member 6 | potassium voltage-gated channel |
| Database Links |
|
| Alphafold | Q9H252 (Hs), O54853 (Rn) |
| CATH/Gene3D | 2.60.120.10 |
| Ensembl Gene | ENSG00000173826 (Hs), ENSMUSG00000001901 (Mm), ENSRNOG00000008078 (Rn) |
| Entrez Gene | 81033 (Hs), 192775 (Mm), 116745 (Rn) |
| Human Protein Atlas | ENSG00000173826 (Hs) |
| KEGG Gene | hsa:81033 (Hs), mmu:192775 (Mm), rno:116745 (Rn) |
| OMIM | 608168 (Hs) |
| Pharos | Q9H252 (Hs) |
| RefSeq Nucleotide | NM_030779 (Hs), NM_173092 (Hs), NM_001037712 (Mm), NM_053937 (Rn) |
| RefSeq Protein | NP_110406 (Hs), NP_775115 (Hs), NP_001032801 (Mm), NP_446389 (Rn) |
| UniProtKB | Q9H252 (Hs), O54853 (Rn) |
| Wikipedia | KCNH6 (Hs) |
| Ion Selectivity and Conductance |
||||||
|
| Voltage Dependence |
||||||||||||||||||||||
|
||||||||||||||||||||||
|
||||||||||||||||||||||
|
||||||||||||||||||||||
| Associated subunits (Human) |
| minK (KCNE1) |
Download all structure-activity data for this target as a CSV file 
| Activators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Activator Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NS1643: Negative shift of activation curve, slows inactivation. These effects are distinct from those of the same compound on Kv11.1 [1] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gating inhibitors
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| View species-specific gating inhibitor tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gating Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| For a review of toxin sensitivity among Kv11 channels, see [10] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
|
||||||||
|
||||||||
|
||||||||
|
||||||||
| Tissue Distribution Comments | ||||||||
| Kv11.1, Kv11.2 and Kv11.3 are broadly expressed in the nervous system [9,12]. In the developing embryonic spinal cord, they regulate nascent spinal motor rhythms [3]. All are expressed in the adult brain in largely overlapping distributions and largely in neuron somata [4]. | ||||||||
| Physiological Functions
|
||||||||
|
||||||||
|
| Biologically Significant Variants
|
||||||||||||
|
||||||||||||
|
1. Elmedyb P, Olesen SP, Grunnet M. (2007) Activation of ERG2 potassium channels by the diphenylurea NS1643. Neuropharmacology, 53 (2): 283-94. [PMID:17610913]
2. Furlan F, Guasti L, Avossa D, Becchetti A, Cilia E, Ballerini L, Arcangeli A. (2005) Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro. Neuroscience, 135 (4): 1179-92. [PMID:16165280]
3. Furlan F, Taccola G, Grandolfo M, Guasti L, Arcangeli A, Nistri A, Ballerini L. (2007) ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. J Neurosci, 27 (4): 919-28. [PMID:17251434]
4. Guasti L, Cilia E, Crociani O, Hofmann G, Polvani S, Becchetti A, Wanke E, Tempia F, Arcangeli A. (2005) Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. J Comp Neurol, 491 (2): 157-74. [PMID:16127690]
5. Mühlbauer E, Bazwinsky I, Wolgast S, Klemenz A, Peschke E. (2007) Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Cell Mol Life Sci, 64 (6): 768-80. [PMID:17322986]
6. Müller R, Thiele J, Klages U, Lingens F. (1984) Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3. Biochem Biophys Res Commun, 124 (1): 178-82. [PMID:6497878]
7. Restano-Cassulini R, Korolkova YV, Diochot S, Gurrola G, Guasti L, Possani LD, Lazdunski M, Grishin EV, Arcangeli A, Wanke E. (2006) Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol Pharmacol, 69 (5): 1673-83. [PMID:16497878]
8. Restano-Cassulini R, Olamendi-Portugal T, Zamudio F, Becerril B, Possani LD. (2008) Two novel ergtoxins, blockers of K+-channels, purified from the Mexican scorpion Centruroides elegans elegans. Neurochem Res, 33 (8): 1525-33. [PMID:18338253]
9. Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, Dixon JE. (1997) Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci, 17 (24): 9423-32. [PMID:9390998]
10. Wanke E, Restano-Cassulini R. (2007) Toxins interacting with ether-à-go-go-related gene voltage-dependent potassium channels. Toxicon, 49 (2): 239-48. [PMID:17097705]
11. Wimmers S, Bauer CK, Schwarz JR. (2002) Biophysical properties of heteromultimeric erg K+ channels. Pflugers Arch, 445 (3): 423-30. [PMID:12466946]
12. Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS. (1997) Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Circ Res, 80 (2): 261-8. [PMID:9012748]
