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Two P domain potassium channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-forming α-subunit contains two pore loop (P) domains and two subunits assemble to form one ion conduction pathway lined by four P domains. It is important to note that single channels do not have two pores but that each subunit has two P domains in its primary sequence; hence the name two P domain, or K2P channels (and not two-pore channels). Some of the K2P subunits can form heterodimers across subfamilies (e.g. K2P3.1 with K2P9.1). The nomenclature of 4TM K channels in the literature is still a mixture of IUPHAR and common names. The suggested division into subfamilies, described in the More detailed introduction, is based on similarities in both structural and functional properties within subfamilies and this explains the "common abbreviation" nomenclature in the tables below.

Channels and Subunits

TWIK1 (K2P1.1) C Show summary » More detailed page

TREK1 (K2P2.1) C Show summary » More detailed page

TASK1 (K2P3.1) C Show summary » More detailed page

TRAAK1 (K2P4.1) C Show summary » More detailed page

TASK2 (K2P5.1) C Show summary » More detailed page

TWIK2 (K2P6.1) C Show summary » More detailed page

K2P7.1 C Show summary » More detailed page

TASK3 (K2P9.1) C Show summary » More detailed page

TREK2 (K2P10.1) C Show summary » More detailed page

THIK2 (K2P12.1) C Show summary » More detailed page

THIK1 (K2P13.1) C Show summary » More detailed page

TASK5 (K2P15.1) C Show summary » More detailed page

TALK1 (K2P16.1) C Show summary » More detailed page

TALK2 (K2P17.1) C Show summary » More detailed page

TRESK (K2P18.1) C Show summary » More detailed page

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Striessnig J, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Voltage-gated ion channels. Br J Pharmacol. 174 Suppl 1: S160-S194.