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Two-pore domain potassium channels (K2P) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-forming α-subunit contains two pore loop (P) domains and two subunits assemble to form one ion conduction pathway lined by four P domains. It is important to note that single channels do not have two pores but that each subunit has two P domains in its primary sequence; hence the name two-pore domain, or K2P channels (and not two-pore channels). Some of the K2P subunits can form heterodimers across subfamilies (e.g. K2P3.1 with K2P9.1). The nomenclature of 4TM K channels in the literature is still a mixture of IUPHAR and common names. The suggested division into subfamilies, described in the More detailed introduction, is based on similarities in both structural and functional properties within subfamilies and this explains the "common abbreviation" nomenclature in the tables below.

Channels and Subunits

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TWIK1 (K2P1.1) C Show summary » More detailed page go icon to follow link

TREK1 (K2P2.1) C Show summary » More detailed page go icon to follow link

TASK1 (K2P3.1) C Show summary » More detailed page go icon to follow link

TRAAK1 (K2P4.1) C Show summary » More detailed page go icon to follow link

TASK2 (K2P5.1) C Show summary » More detailed page go icon to follow link

TWIK2 (K2P6.1) C Show summary » More detailed page go icon to follow link

K2P7.1 C Show summary » More detailed page go icon to follow link

TASK3 (K2P9.1) C Show summary » More detailed page go icon to follow link

TREK2 (K2P10.1) C Show summary » More detailed page go icon to follow link

THIK2 (K2P12.1) C Show summary » More detailed page go icon to follow link

THIK1 (K2P13.1) C Show summary » More detailed page go icon to follow link

TASK5 (K2P15.1) C Show summary » More detailed page go icon to follow link

TALK1 (K2P16.1) C Show summary » More detailed page go icon to follow link

TALK2 (K2P17.1) C Show summary » More detailed page go icon to follow link

TRESK (K2P18.1) C Show summary » More detailed page go icon to follow link

Comments

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Ion channels. Br J Pharmacol. 176 Issue S1: S142-228.