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Inwardly rectifying potassium channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

Channels and Subunits

Kir1.1 C Show summary » More detailed page

Kir2.1 C Show summary » More detailed page

Kir2.2 C Show summary » More detailed page

Kir2.3 C Show summary » More detailed page

Kir2.4 C Show summary » More detailed page

Kir3.1 C Show summary » More detailed page

Kir3.2 C Show summary » More detailed page

Kir3.3 C Show summary » More detailed page

Kir3.4 C Show summary » More detailed page

Kir4.1 C Show summary » More detailed page

Kir4.2 C Show summary » More detailed page

Kir5.1 C Show summary » More detailed page

Kir6.1 C Show summary » More detailed page

Kir6.2 C Show summary » More detailed page

Kir7.1 C Show summary » More detailed page

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Striessnig J, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Voltage-gated ion channels. Br J Pharmacol. 174 Suppl 1: S160-S194.