tolbutamide   Click here for help

GtoPdb Ligand ID: 6848

Synonyms: Orinase® | tolbutamide sodium
Approved drug
tolbutamide is an approved drug (FDA (1979))
Compound class: Synthetic organic
Comment: A sulfonylurea family drug inhibiting sulfonylurea receptor 1 (ABCC8)/Kir6.2 ( KCNJ11).
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 83.65
Molecular weight 270.1
XLogP 2.18
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CCCCNC(=O)NS(=O)(=O)c1ccc(cc1)C
Isomeric SMILES CCCCNC(=O)NS(=O)(=O)c1ccc(cc1)C
InChI InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1979))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
602 tolbutamide
Synonyms Click here for help
Orinase® | tolbutamide sodium
Database Links Click here for help
CAS Registry No. 64-77-7
DrugBank Ligand DB01124
DrugCentral Ligand 2696
GtoPdb PubChem SID 178103454
PubChem CID 5505
Search Google for chemical match using the InChIKey JLRGJRBPOGGCBT-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JLRGJRBPOGGCBT
Search PubMed clinical trials tolbutamide
Search PubMed titles tolbutamide
Search PubMed titles/abstracts tolbutamide
UniChem Compound Search for chemical match using the InChIKey JLRGJRBPOGGCBT-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey JLRGJRBPOGGCBT-UHFFFAOYSA-N
Wikipedia Tolbutamide