Ligand id: 6848

Name: tolbutamide

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 83.65
Molecular weight 270.1
XLogP 2.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir6.2 Rn Channel blocker Antagonist - - 5x10-4 2
Conc range: 5x10-4 M [2]
Voltage: -60.0 mV
Kir6.2 Mm Channel blocker Antagonist 4.5 pIC50 - 1
pIC50 4.5 [1]
Voltage: Physiological
Kir6.1 Hs Inhibitor - - - -
Kir6.2 Hs Inhibitor - - - -