ChEMBL ligand: CHEMBL132966 (Rivanicline, TC-2403)
nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human [ChEMBL: CHEMBL1907594] [GtoPdb: 474, 464] [UniProtKB: P30926, P32297] This target only has 1 pki data point 1 CHEMBL132966_lig_chart_1 Neuronal acetylcholine receptor; alpha3/beta4 Human There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681] nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390] 2 CHEMBL132966_lig_chart_2 Neuronal acetylcholine receptor; alpha4/beta2 HumanRat There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941] 3 CHEMBL132966_lig_chart_3 Neuronal acetylcholine receptor protein alpha-7 subunit HumanRat There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α3 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907594] [GtoPdb: 474, 464] [UniProtKB: P30926, P32297]
ChEMBL	Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in human SH-SY5Y cells	B	5.27	pKi	5400	nM	Ki	J. Med. Chem. (2012) 55: 9929-9945 [PMID:23025891]
ChEMBL	Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic)	B	4.34	pEC50	46000	nM	EC50	J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889]
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681]
ChEMBL	Displacement of [3H]nicotine from human alpha4beta2 nAChR expressed in human SH-EP1 cells	B	7.59	pKi	26	nM	Ki	J. Med. Chem. (2012) 55: 9929-9945 [PMID:23025891]
GtoPdb	Binding affinity for the α4β2 nicotinic acetylcholine receptor.	-	7.6	pKi	~25	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 523-6 [PMID:14698195]
ChEMBL	Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2	B	7.6	pKi	25	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 523-526 [PMID:14698195]
ChEMBL	Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2	B	5.37	pEC50	4300	nM	EC50	J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889]
nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390]
ChEMBL	Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain	B	7.59	pKi	26	nM	Ki	J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889]
ChEMBL	Displacement of [3H]L-nicotine from alpha-4-beta-2 nAChR in rat cerebral cortex	B	7.59	pKi	26	nM	Ki	Bioorg. Med. Chem. Lett. (2008) 18: 188-193 [PMID:18006307]
GtoPdb	-	-	7.59	pKi	26	nM	Ki	J. Pharmacol. Exp. Ther. (1996) 279: 1413-21 [PMID:8968366]
ChEMBL	Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2	B	6.14	pEC50	730	nM	EC50	J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL	Displacement of [3H]epibatidine from human alpha7 nAChR expressed in human HEK/RIC3 cells	B	5.1	pKi	8000	nM	Ki	J. Med. Chem. (2012) 55: 9929-9945 [PMID:23025891]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
ChEMBL	Affinity for Nicotinic acetylcholine receptor alpha7	B	4.44	pKi	36000	nM	Ki	J. Med. Chem. (1997) 40: 4169-4194 [PMID:9435889]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]