CPFPX [Ligand Id: 5603] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2311146
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
  • A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL In vitro binding affinity for porcine Adenosine A1 receptor B 8.86 pKd 1.37 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
ChEMBL In vitro binding affinity for human Adenosine A1 receptor expressed in CHO-K1 cells B 8.9 pKd 1.26 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
GtoPdb - - 8.9 pKi 1.26 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL In vitro binding affinity for Adenosine A1 receptor of bovine cortex B 9.74 pKi 0.18 nM Ki J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL In vitro binding affinity at rat Adenosine A1 receptor B 9.2 pKd 0.63 nM Kd J Med Chem (2002) 45: 5150-5156 [PMID:12408725]
GtoPdb - - 9.2 pKi 0.63 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 6.03 pKi 940 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
GtoPdb - - 6.09 pKi 812 nM Ki J Med Chem (2002) 45: 5150-6 [PMID:12408725]
ChEMBL In vitro binding affinity at Adenosine A2A receptor of rat cortex B 6.09 pKi 812 nM Ki J Med Chem (2002) 45: 5150-5156 [PMID:12408725]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]