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talampicillin   Click here for help

GtoPdb Ligand ID: 12289

Synonyms: BRL 8988 | Talpen®
Approved drug
talampicillin is an approved drug
Compound class: Synthetic organic
Comment: Talampicillin is a semisynthetic penicillin belonging to the β-lactam group of antibacterial compounds. It is an orally administered prodrug of ampicillin [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 153.33
Molecular weight 481.13
XLogP 2.43
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C([C@@H](c1ccccc1)N)N[C@@H]1C(=O)N2[C@@H]1SC([C@@H]2C(=O)OC1OC(=O)c2c1cccc2)(C)C
Isomeric SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](c1ccccc1)N)C(=O)OC1c2ccccc2C(=O)O1)C
InChI InChI=1S/C24H23N3O6S/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28)/t15-,16-,17+,20-,23?/m1/s1
InChI Key SOROUYSPFADXSN-SUWVAFIASA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes.
Is prodrug? Yes
Active form ampicillin
IUPAC Name Click here for help
(3-oxo-1H-2-benzofuran-1-yl) (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
International Nonproprietary Names Click here for help
INN number INN
3607 talampicillin
Synonyms Click here for help
BRL 8988 | Talpen®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Talampicillin
Other databases
CAS Registry No. 47747-56-8 (source: Scifinder)
ChEBI CHEBI:9391
ChEMBL Ligand CHEMBL1619785
DrugBank Ligand DB13814
DrugCentral Ligand 2554
GtoPdb PubChem SID 479821080
PubChem CID 71447
Search Google for chemical match using the InChIKey SOROUYSPFADXSN-SUWVAFIASA-N
Search Google for chemicals with the same backbone SOROUYSPFADXSN
Search PubMed clinical trials talampicillin
Search PubMed titles talampicillin
Search PubMed titles/abstracts talampicillin
UniChem Compound Search for chemical match using the InChIKey SOROUYSPFADXSN-SUWVAFIASA-N
UniChem Connectivity Search for chemical match using the InChIKey SOROUYSPFADXSN-SUWVAFIASA-N