trodusquemine [Ligand Id: 9733] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL508583 (MSI-1436, Trodusquemine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of PTP1B | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2011) 19: 2145-2155 [PMID:21420867] |
| GtoPdb | In a cell-free assay using recombinant enzyme. | - | 6 | pIC50 | 1000 | nM | IC50 | Obesity (Silver Spring) (2010) 18: 1516-23 [PMID:20075852] |
| ChEMBL | Inhibition of recombinant PTP1B | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 730-733 [PMID:21193311] |
| ChEMBL | Inhibition of full length PTP1B (unknown origin) after 30 mins by ELISA | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2015) 23: 2786-2797 [PMID:25921264] |
| ChEMBL | Inhibition of full length PTP1B (unknown origin) by ELISA | B | 6 | pIC50 | 1000 | nM | IC50 | J Nat Prod (2020) 83: 1598-1610 [PMID:32255628] |
| ChEMBL | Inhibition of human recombinant PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated with substrate for 10 mins followed by enzyme addition and measured for 10 mins by absorbance based analysis | B | 6 | pIC50 | 1000 | nM | IC50 | J Nat Prod (2021) 84: 2454-2467 [PMID:34460246] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
